Influence Of Alcohol Consumption On Early Postoperative Cognitive Function Under General Anesthesia In The Patients

Objective:To explore the influence of alcohol consumption on early postoperative cognitive function under general anesthesia in the patients and to provide evidence for preoperative prevention. Methods:An epidemiological survey provided by WHO was performed in the patients through face-to-face interview, which was used to record general information and the history of alcohol intake and diseases within the past years, the risk of alcohol consumption is considered to be high. Forty chronic alcoholics and 40 matched controls received neuropsychological test, the assessment of postoperative cognitive function referred to the scores that achieved in neuropsychological testing with mini mental state examination(MMSE) by special psychological person on the day before and the third day after surgery which was under general anesthesia. Finally, self-group difference and inter-group difference were compared. Results:There were no statistical differences between the two groups with respect to sex,age,weight,height,type of operation, but also in several factors, such as the time of the anesthesia, the low MAP in the operation, preoperative CAD and COPD, the amount of atropine administration and the degree of hypotension, general health condition, mental status, medicine treatment, intra-operative management, and so on. The score of MMSE was lower in exposure group on the third day after surgery than made on the first day before surgery(P<0.05). There were no statistical differences between the score of MMSE on the first day before surgery and on the third day after surgery in control group(P>0.05). The score of MMSE was lower in exposure group than control group on the third day after surgery(P<0.05). The incidence of POCD on the third day after surgery was higher in exposure group than control group(37.5% vs.10.0%) (P<0.05). Conclusion: Drinking alcohol heavily and chronically may promote the incidence of damage on early postoperative cognitive function in the patients under general anesthesia, which should draw more attention of the doctors and patients. The results suggest that appropriate intervention measures are needed in the patients.