Ozone Autologous Blood Transfusion Treatment On The Fatty Liver Of Serum Cytokines

Objective:The aim of this study was to assess the effect of ozone treatment on leptin, interleukin-6 (I-6L), high sensitivity C-reactive protein (hs-crp), NO, oxidized low-density lipoprotein (oxLDL),8-iso-prostaglandin F2a (8iso-PGF2a) levels in patients with non-alcoholic fatty liver disease (NAFLD). Methods:The study conducted at the Hepatology Department of First Affiliated Hospital of Xinjiang Medical University.Thirty-six FLD patients were selected, who were not undergoing any antioxidant treatment were divided into treatment and control groups. The treatment group comprised patients who willingly received ozone-enriched autologous blood transfusion (OATT). Patients with type 2 diabetes mellitus (T2DM) or dyslipidemia received professional guidance for lowering of blood lipids and sugar treatment. Patients in the treatment group received OATT, while the patients in the control group did not receive any antioxidant treatment. Results:There were no significant intergroup differences with regard to the age, body mass index (BMI), ethnicity, sex, T2DM, and dyslipidemia. The baseline serum leptin (P= 0.03) levels were significantly higher and 8iso-PGF2a (P= 0.00) levels significantly lower in the treatment group than those in the control group. No significant intergroup difference was observed in the serum leptin levels at the end of the study period. Conclusion:Ozone intervention decreased serum leptin levels of FLD patients in only 5 weeks. However, further clinical studies need to be performed to identify the potential for the use of ozone as an antioxidant in patients with FLD, and the mechanism(s) that improve leptin resistance in patients who receive ozone.