The Clinical Analysis Of Juvenile Patients With Retinitis Pigmentosa

1.Background and ObjectiveRetinitis pigmentosa (RP) is a genetically chronic eye disease that characterised with night blind and progressed visual defect by degeneration of retinal photoreceptor cell and pigment epithelium. The typical fundus of this disease show that the optic disc has a waxy pallor, the vessels are thin and the presence of bone spicule-shaped pigment deposits. The check of visual fields, electroretinogram (ERG) and optical coherence tomography (OCT) play important roles in early diagnosis and differential diagnosis of this disease. So far, the disease is still lack of effective treatment. With the development of genetic engineering, biochemical technology and animal models, retinal transplantation and gene therapy are expected to be the best choice for the patients with RP. Though RP can occur at any age, it is more common seen in 20 to 40 years old patients and relatively rare occur in juveniles. So this article is aimed to discuss the clinical features of juvenile patients with RP through observation and analysis two typical cases of juvenile patients with RP in our hospital, and promote the awareness of juvenile patients with RP. 2. Material and MethodTwo cases of juvenile patients with RP from the ophthalmology department of 1st affiliated hospital of Zhejiang University were reported and analyzed. Simultaneously, we searched the literatures in the PubMed database of the National Library of Medicine Online, China national knowledge Internet (CNKI) and VIP information database, to review and analysis.3.Results and ConclusionsThe symptoms of two patients and their results of visual field, ERG and OCT meet the diagnosis of RP. Also there are some special performance of fundus examination and photography. The check of visual field and ERG can help us to diagnose and evaluate the disease. The pathogenesis and treatment of juvenile patients with RP require further research and in-depth.