The Research Of Calcium, Phosphorus Concentrations In Saliva Of Patients With Nasopharyngeal Carcinoma Before And After Radiation Therapy

Purpose:Analyze caries activity of patients with nasopharyngeal carcinoma before and after radiation therapy. The study was also designed to analyze calcium, phosphorus concentrations in saliva of NPC patients before and after radiation therapy and healthy controls, to investigate the influence of radiation therapy, in order to provide the basis for the etiology and prevention of radiation caries.Method:28 NPC patients patients and 20 healthy controls were concluded in this study. Resazurin disc method was used to detect caries activity of NPC patients before and after 70Gy radiation therapy. The atomic absorption spectrometry and mo-sb antispetrophotography method were used to analyze calcium, phosphorus concentrations in saliva of NPC patients before and after 70Gy radiation therapy and 20 healthy controls.Results:â‘ The result of Resazurin disc method shows caries activity of NPC patients increased before and after radiotherapy (P<0.05).â‘¡Calcium concentrations in saliva of NPC patients before radiation therapy were 63.19mg/l, after 70 Gy radiation therapy were 33.38mg/l. The difference was significant (P< 0.01). Phosphorus concentrations in saliva of NPC patients before radiation therapy were 132.96mg/1, after 70 Gy radiation therapy were 49.18mg/1. The difference was significant (P < 0.01).The difference of calcium, phosphorus concentrations in saliva between male and female NPC patients before and after 70 Gy radiation therapy was not significant (P> 0.05). The difference of the results of calcium, phosphorus concentrations before radiation therapy subtracted concentrations after 70 Gy between male and female NPC patients was not significant (P> 0.05).The difference of calcium, phosphorus concentrations in saliva between III stage and IVa stage NPC patients before and after 70 Gy radiation therapy was not significant (P> 0.05). The difference of the results of calcium, phosphorus concentrations before radiation therapy subtracted concentrations after 70 Gy between III stage and IVa stage NPC patients was not significant (P> 0.05).Conclusion:â‘ Caries activity were increased after 70 Gy radiation therapy.â‘¡Calcium, phosphorus concentrations in saliva of NPC patients were influenced by radiation therapy. Calcium, phosphorus concentrations in saliva were reduced after 70 Gy radiation therapy. The difference of calcium, phosphorus concentrations in saliva of NPC patients before and after 70 Gy radiation therapy showed no significant correlation by gender and clinical stage.