Clinical Analysis Of Primary Biliary Cirrhosis Combined With Diabetes Mellitus

BackgroundPrimary biliary cirrhosis (PBC) is an autoimmune disease characterized by progressive cholestasis, which can finally develop into liver fibrosis, cirrhosis and liver failure. The nearest reported incidence of PBC combined with diabetes mellitus (DM) was between 2.54% and 12.8%. DM can aggravate cholestasis and liver damage, thus unfavorable to the prognosis of patients with PBC. To explore the clinical features of patients with PBC and DM can provide clinical evidence for the early diagnosis and treatment on DM in patients with PBC. This has not been reported until now.ObjectiveTo explore the incidence and clinical features of patients with PBC and DM.MethodsEighty-one patients with PBC were divided into two groups: PBC combined with DM group (DM group) and PBC only group (non-DM group). For these two groups, we retrospectively analyzed the general data, clinical features, complications, liver function index and immunologica1 features.Results1. The incidence of PBC combined with DM was 19.6%.2. For the two groups, the symtoms of malaise, anorexia, abdominal distension were common, whereas the symtoms of polydipsia, polyuria, polyphagia and weight loss. And the incidences of all these symptoms did not differ significantly between the two groups.3. The incidences of leg edema, ascites and hydrothorax complications in the DM group (43.8%; 75.0%; 25%) were obviously higher than those in the non-DM group (15.4%; 30.8%; 3.1%; P=0.03, P=0.001, P=0.01).4. The levels of anti-mitochondrial antibody were both more than 1:100 in the two groups. The level of anti-mitochondrial antibody M2 (AMA-M2) in the DM group was (91.3±65.7) Ru/ml, significantly lower than that in the non-DM group (171.1±84.0 ) Ru/ml (P=0.03).5. Age, sex and liver function index did not differ significantly between the two groups.ConclusionThe clinical manifestations of liver disease are more common than the symptoms of polydipsia, polyuria, polyphagia and weight loss in patients with PBC and DM. For patients with PBC, especially complicated with leg edema, ascites and hydrothorax, we should monitor the level of serum glucose in order to timely diagnose and treat on DM.