Analysis Of The High Risk Factors And Prognosis On Coronary Aneurysms Secondary To Kawasaki Disease

ObjectiveTo explore the high risk factors and prognosis of coronary aneurysm (CAA) caused by Kawasaki disease(KD).MethodsClinical data of 3902 patients with KD admitted in Children′s hospitol of Chongqiing Medical University from January,1993 to December,2009 were collected and retrospectively reviewed: Risk factors associated with coronary artery lesion such as sex,age,fever,timing of IVIG,WBC,Hb,PLT,ESR,CRP,albumin,CK-MB were analyzed. Chi-square test and Logistic regression were performed; The followed-up 46 CAA cases's recovery situation in 1 month, 3 month, 6 month, 1, 2, 3, 4, 5 years , larger than 5 years and the long term clinical effect of different IVIG doses were analyzed.χ~2 test were performed.Results(1)Chi-square test showed that gender, male, age, duration of fever, administration time of IVIG, heamoglobin (Hb), erythrocyte sedimentation rate (ESR) and serum albumin were significantly related to CAA(P<0.05). Multiple Logistic regression analysis identified Hb, ESR and the administration time of IVIG were independent risk factors of CAA(P<0.05). (2) The retraction time of small CAA, middle CAA and GCAA are gradually extended(P<0.05). Different dosage of IVIG and different age were not significant related to retraction duration of different sizes of CA A (P>0.05).ConclusionHb<100 g/L ,ESR >50mm/h and the administration time of IVIG later than 10th days are the high risk factors of CAA caused by KD. The retraction durations of CAA was associated with CAA's size, and were not associated with dosage of IVIG and age.