The Expression Of BCL-2 In Acute Leukemia Of Different Pathological States And The Relationship With The Chemotherapeutic Efficacy Based On Meta-Analysis

Objective To investigate the expression of Bcl-2 in acute leukemia of different pathological states and their relationship with chemotherapeutic efficacy.Methods We collected case-control trials and cohort study by searching the electronic biblliographic databases, and handsearching journals. To identify all the relevant trials. The quality of the included studies were assessed. The Cochrane Cllaboration's software RevMan 5.0 was used to test the combined studies.Results A total of 11 studies were included. Meta analysis showed that The complete remission of acute leukemia with Bcl-2 positive was lower than The Bcl-2 negative patients after chemotherapy[OR=0.26,95%CI ( 0.14 , 0.46 ) ]; In acute lymphocytic leukemia and acute non-lymphocytic leukemia, the difference of Bcl-2 positive rate were not statistically significant [OR = 0.87,95% CI (0.46,1.65) ]; After chemotherapy, Bcl-2 positive rate in complete remission patients was significantly lower than non-complete remission[SMD= - 0.87,95%CI(-1.53,-0.20),P=0.01].Conclution According to domestic evidence, Bcl-2 showed a significant correlation with the remission rate and the chemotherapeutic efficacy in acute leukemia patients, the above conclusion needs more high-quality studies for further confirmed.