The Correlation Between Blood Glucose Level And The Incidence Of Maklignant Venttricular Arrhythmias In Patients With Acute Myocardia Infarction

Objecti1. The aim of this study was to explore the relationship of fasting blood glucose levelin the patients with malignant ventricular arrhythmias suffering from acutemyocardial infarction in hospital.2. It was to explore the relationship of fasting blood glucose level and in-hospitalmortality in patients with acute myocardial infarction .MethodsA total of 1118 patients with acute myocardial infarction were enrolled and assignedinto three groups(A, B and C) according to the fasting glucose level(<6.99 mmol/L,7.00-11.09mmol/L and≥11.10 mmol/L). They were divided into non-diabeticsubgroup and type 2 diabetic subgroup according to diabetic history, and then toanalyze the incidence of malignant ventricular arrhythmias and in-hospital mortalityamong the different groups.Results1. All the patients in three groups were 72.3% (n=808), 21.4% (n=239), and 6.4%(n=71), respectively. The incidence of malignant ventricular arrhythmias weresignificantly different among three groups with 6.20%, 7.90% and 19.70%,respectively,P<0.001. Furthermore, the incidence of malignant ventriculararrhythmias increased with the rise of blood glucose level. This difference was moreapparent among three groups in the non-diabetic patients(5.90% vs 10.20% vs33.30%,P<0.001). However, there were no difference among three groups in thediabetic patients ( 8.20% vs 5.40% vs 12.80%, P=0.277). Multiple logistic regression model identified fasting glucose level≥11.10 mmol/L within 24h after admission innon-diabetic patients has the highest risk with in-hospital malignant ventriculararrhythmias in acute myocardial infarction(OR=6.680,95%CI 2.647-16.885, P<0.001).2. Higher glucose levels were associated with increased risk of death (group A :3.10%vs group B :7.90% vs group C: 22.50%;P<0.001). Multiple logistic regression modelidentified patients with higher fasting glucose tended to have increased risks for inhospitalmortality. As compared with group A, the group C and group B had a risk of inhospitaldeath of 2.37 folds(OR=2.370,95% CI 1.112-5.054;p=0.02)and 4.47folds(OR =4.465,95%CI 1.755 - 11.359;P=0.002) .ConclusiConclusion1. Elevated fasting glucose (≥11.10mmol/L)is associated with increased risk ofmalignant ventricular arrhythmias in acute myocardial infarction and maybe moreobvious in patients with a previous history of diabetes.2. Higher fasting glucose levels had poor influences on the prognosis of acutemyocardial infarction patients．Higher fasting glucose levels are independently inhospitaldeath risk factor of patients.