| Objective To study the pharmacokinetics process about recombinant human endostatin in monkeys by Subcutaneous and intravenous administration. To provide the reference about rational drug using for the clinical.Methods The concentration and radioactivity of recombinant human endostatin in blood were calculated by High Performance Liquid Chromatography and Radioactive detection. for what calculate pharmacokinetic parameters.Results The main pharmacokinetic parameters of intravenous and subcutaneous administration were t1/2α 254min, t1/2β 764 min,MRT 969min,AUC 2893μg/ml·min;Cmax 4.01μg/ml,Tmax 30min,MRT 1982min,AUC 2502μg/ml·min respectively. The total urinary excretion of endostatin were 31% and 24% respectively when 48 hours after intravenous and 72 hours after Subcutaneous injection.Conclusion Subcutaneous administration has a faster and higher process of absorption.and the absolute bioavailability is 86.5%,Which Suggest subcutaneous administration is a reasonable way.
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