Influential Factor Affect Prognosis Of Adult Granulosa Cell Tumor Of Ovary

Objective: To analyze retrospectively the clinical information of 37 patients with adult granulosa cell yumor of ovary during 8 years in the Fourth Hospital of Hebei Medical University and the Second Hospital of HebeiMedical University. To evaluate the related risk factors affecting prognosis and the relationship between various clinicopathologic factors. Methods: The clinical factors and outcomes of 37 patients with adult granulosa cell yumor of ovary underwent primary surgical treatment and confirmed by pathology from Jan 2002 to Dec 2010 in the Second Hospital of Hebei Medical University and Jan 2006 to Dec 2010 in the Fourth Hospital of Hebei Medical University were reviewed and analyzed. An Excel database was built with clinical follow-up survey and analyze the prognostic factors of the adult granulosa cell tumor of ovary.SPSS 13.0 software package was used.Survival rates were calculated using Kaplan-Meier method.Evaluated the prognostic factors by univariate and multivariate analysis. Univariate analysis and the comparison between the survival rates was estimated by log-rank test. Multiple regression analysis were assessed by Cox proportional hazards model. Enumeration data were compared withχ2 test.A statistically significant difference was indicated by P<0.05.Results:1 The number of patients who′s age greater than or equal 40 was more than the number of patients who′age less than 40. The main clinical symptoms was irregular bleeding of vagina and abdominal pain. Clinical stageⅠwas the most than other stage.The number of menopause was more than not. The most diameter of tumor was larger than 10cm. Patients who underwent hysterectomy +salpingo-oophorectomy, Prognosis was good. The recurrent time of patients who′age less than 40 was shorter than that who′s age greater than or equal 40.2 The average survival time of 37 cases with granulosa cell tumor of ovary was 52.31 month, survival time was 1month~90month, one side ovary was 94.5%, two sides ovary was 5.4%.3 The 1-year, 3-year, 5-year overall survival rates after surgery were 94.4%,90.5%,90.5%, respectively.4 The age was from 15 years old to70 years old. The median age was 40 years old; <40 acount for 32.4%,≥40 67.6%.5 In the two age groups, there was no difference statistically in menopausal state, tumor size, intimal thickness, clinical stage, recurrence, therapeutic method (P>0.05).6 Univariate analysis revealed that age, menopausal state, tumor size, intimal thickness, scavenge lymph nodes, therapeutic method, were not signify- cantly associated with the overall-survival rate. Clinical stage, recurrence, surgical range, were significantly associated with the survival rate. Multivariate analysis revealed that clinical stage was independent prog- nostic factor of granulosa cell tumor of ovary.7 The 5-year overall survival rates after surgery of patients with stageⅠgranulosa cell tumor of ovary was 96.6%, recurrence rate was 12.9%. Who underwent simple salpingo-oophorectomy, hysterectomy+salpingo-oopho- rectomy, hysterectomy+salpingo-oophorectomy+greater omentum+appen- dix or lymph nodes. Five-year survival rates were 93.5%,100%,100%, respectively, there was no difference statistically (P>0.05). Patients with stageⅠunderwent simple surgery, surgery+chemotherapy, surgery+hemoth- erapy+radiotherapy.Five-year survival rates were 95.8%,97.8%,100%, respectively, there was no difference statistically (P>0.05). Prognosis was good.8 Age, clinical stage, tumor size, were no difference statistically with recu- rrence (P>0.05). Surgical range, therapeutic method, were difference statistically with recurrence (P<0.05). Conclusion:1 The number of≥40 age patients was more than the number of <40 age. The main clinical symptoms were irregular bleeding of vagina and abdominal pain. Clinical stageⅠwas the most than other stage. The most diameter of tumor was larger than 10cm. Patients underwent hysterectomy+ salpingo- oophorectomy. Prognosis was good.2 The survival rate of clinical stageⅠwas higher than clinical stageⅡ, The survival rate of clinical stageⅡwas higher than clinical stageⅢ.3 Clinical stage, surgical range, and recurrence, were signifycantly associated with survival rate. Surgical range and therapeutic method were signifycantly associated with recurrence.4 Surgical range and therapeutic method were not associated with survival rate and recurrence. Extensive surgical range of stageⅠadult granulosa cell tumor of ovary does not increase the survival rate.5 The clinical stage was the independent factor of adult granulosa cell tumor of ovary.6 The prognosis of adulte granulosa cell tumor of the ovary was closely related to clinical stage, surgical range, therapeutic method. We should assess systematicly prognostic correlative factors of adult granulosa cell tumor of the ovary.