Clinical Efficacy Research Of Treating Chronic Kidney Disease (Syndrome Of Deficiency Of Qi, Blood Stasis And Toxic Damp-heat) With Rhubarb In Different Dosage

With careful instruction by the supervisor, Professor Li Mingquan, the author of the thesis observed, organized and summarized the academic theory and clinical experience of Professor Li Mingquan who treats chronic kidney disease with Rhubarb and discussed the theory, principle, formula and herbs deeply of CKD guided by foundational theory of Traditional Chinese Medicine.ObjectiveRhubarb has already been used widely in treating chronic kidney disease. Clinical and animal experiment has fully proved to be medicable. But at the present time, there is no universally accepted academic viewpoint about Rhubarb dosage and security.So, the objective of this dissertation is discussing the effectiveness and security of Rhubarb in different dosage treating chronic kidney disease for clinical application and observing the effectiveness of Rhubarb treating the syndrome of deficiency of qi, blood stasis and toxic damp-heat.MethodsThe research samples are 18 patients with explicitly diagnosed chronic kidney disease,divided into 2 treatment groups (with 9 cases in each treatment group) by a random, alternative and contrastive test method. After leading-in and observing stage, the author prescribe the basic formula adding Rhubarb in 9 or 3 gram to A treatment groups,3 gram to B treatment groups.One formula is used just for one day. Decocting medicinal herbs and drinking the herbs juice every day for 4 weeks. After 4 weeks, the patients will have an elution stage for 2 weeks. Then they will have the formula adding 3or 9 gram Rhubarb exchange for 4 weeks. We observe the syndrome,Scr and BUN throughout the treating stage.ResultTreating chronic kidney disease (syndrome of deficiency of qi, blood stasis and toxic damp-heat) with Rhubarb has proved to be effective. The improvement mainly focuses on syndrome improving in this research. The application of Rhubarb in 9 grams is better than the application of Rhubarb in 3 grams for improving the syndrome of chronic kidney disease as same as the efficiency. But there's no statistical significance.There is no abnormal phenomena relating to Rhubarb through the research viewed from the results of examining blood routing,urine routing,stool routing,liver function,kidney function,electrolyte and ECG, which means Rhubarb is safe, although there are some light untoward effects in the research.ConclusionUsing Rhubarb to treat chronic kidney disease is one of the effective methods because it could make clinical symptoms improved. The application of Rhubarb in 9 grams is better than the application of Rhubarb in 3 grams for improving the syndrome of chronic kidney disease as same as the efficiency. But there's no statistical significance.Rhubarb is one of the effective herbs in treating chronic kidney disease.