Expression And Significance Of Chibby In Nasopharyngeal Carcinoma

Background and Objective:Nasopharyngeal carcinoma (NPC) is one of the common head and neck cancers, which incidence rate is in the first head and neck cancer. In recent years, a large number of studies have shown that there is a close relationship between wnt/β-catenin signaling pathway and the development of NPC.β-catenin ,a critical factor of Wnt/β-catenin signaling pathway ,combined with nuclear transcription factor TCF / LEF , starts with the expression of target gene. This is the critical step of the activation of signaling pathway. chibby ,aβ-catenin inhibitor, prevent expression of target gene through inhibition ofβ-catenin .It may be a potential tumor suppressor. We analyse the Chibby expression and its function in NPC.Material and Methods:Forty-five cases of NPC were included in this study. Tumour and matched contralateral mucosa were sampled. Chibby expression levels were investigated by quantitative RT-PCR, and immunohistochemical methods revealed correct expression patterns of Chibby protein. The chibby expression levels and expression patterns of Chibby protein in different groups of different characters were analysed.Result:The rate of low expressions of Chibby mRNA is in tumour 68.9% (31/45 95% CI 53%-82%), the expressions in the tumour and matched contralateral mucosa were 0.0776±0.0059 and 0.0835±0.0056(P<0.05). The rate of low expressions of Chibby protein in tumour is 73.3% (33/45, 95% CI 58%-85%), the positive rate in the tumour and matched contralateral mucosa were 42.2%(19/45) and 91.1%(41/45), P<0.05. The early tumour staging and the clinical staging had the low chibby expression levels and expression patterns of Chibby protein.Conclusion:There is low expression of Chibby mRNA and protein in NPC, The chibby expression levels and expression patterns of Chibby protein associate with tumour staging and clinical staging.