Evidence-based Treatment In Chronic Idiopathic Thrombocytopenic Purpura In Adults: Does Splenectomy Affect Curative Effect Of Rituximab Or Not?

ObjectiveThe objective of this study is to find evidence-based treatment in chronic idiopathic thrombocytopenic purpura in adults, does splenectomy affect curative effect of rituximab or not?Subjects and MethodsData were searched in The Cochrane Library (Issue 3,2010), MEDLINE (with PubMed,1966 to Nov.2010), EMbase (1984 to Nov.2010), CBMdisc (1978 to Nov.2010), CNKI (1979 to Nov.2010), VIP(1979 to Nov.2010), and wangfang (1979 to Nov.2010), The data were extracted, and then the quality of the included studies was assessed strictly. RevMan 5.0 software was used for meta-analyses.ResultsWe included 18 prospective trials, with total of 299 patients met the included criteria, divided into splenectomized group and non-splenectomized group.The meta-analysis showed that splenectomy does not affect curative effect of rituximab in chronic idiopathic thrombocytopenic purpura in adults.ConclusionSplenectomy does not affect curative effect of rituximab in chronic idiopathic thrombocytopenic purpura in adults.