The Curative Effect Of Julisanjie Tablet Joint Mifepristone In Treating Uterine Myoma

Uterine myoma is a kind of gynecologic common benign tumor. Western medicine is used to surgical treatment for patients. But the operations bring certain burden to the patients's physiology, mentality and economy. More and more people pay attention to the cure with medicine of uterine myoma. Mifepristone which has been proved by experiment and clinic is a really effective drug for uterine myomas. But it has some side effects. The quantity of Mifepristone is not positive in clinical reports. Is there a dosage that not only can reach the same levle in reducing myoma just as the dosage uesd in clinical reports(12.5mg/d), but also make fewer side effects? Julisanjie tablet which treat uterine myoma from the whole of human body can regulate Qi, Xue, Yin and Yang. The past studies have proved Julisanjie tablet can reduce volume effectively, and it has little side effects. We establish this research which is to observe the curative effect of Julisanjie tablet combined small doses mifepristone whether can do better than single mifepristone or single Julisanjie tablet in treating uterine myoma in the clinical. Whether Julisanjie tablet combined small doses mifepristone not only can reduce the side effects caused by mifepristone influences alone but also have a better long-term follow-up.MethodChoose standard 45 cases of myoma uterus, randomly divided into three groups:15 cases of integrated traditional Chinese and western medicine group: These patients take 4 slices Julisanjie tablet 3 times a day. They also take 5mg mifepristone twice a week. Julisanjie tablet are stopped taking during the menstruation. Mifepristone is started taking on the first day of the menstrual cycle. They will continuous take these pills 3 months for one period of treatment.There are 15 cases in the traditional Chinese medicine group:These patients take 4 slices Julisanjie tablet 3 times a day which are stopped taking during the menstruation. They will continuous take these pills 3 months for one period of treatment.There are also 15 cases in the Western medicine group:They take 5mg mifepristone twice a week. Mifepristone is started taking on the first day of the menstrual cycle. They will continuous take these pills 3 months for one period of treatment.All of the patients should do the pelvic B ultrasonic examination in order to measure three diameter line of uterine myomas before and after the treatment. We calculate the volume of the uterine myomas. They also check blood analysis detection(The patients who take mifepristone should be monitored the Liver and kidney function). After discontinuation of follow-up of 3 months, the patients will review pelvic B ultrasonic examination and blood analysis detection.We use the SPSS13.0 statistical software to compile statistics the data.ResultThe three groups of patients in age, fibroid volume before treatment, and hemoglobin content, etc were no significant difference (P>0.05), so they are comparable.(1) 12 cases were effective in Traditional Chinese medicine group, and the group's effective rate was 80%. 11 cases were effective in Western medicine group, and the group's effective rate was 73%. All cases of integrated traditional Chinese and western medicine group were equally effective, and the group's effective rate was 100%. The fibroid volume and hemoglobin content of the three groups had significant differences after treatment. The curative effect of integrated traditional Chinese and western medicine in reducing fibroid volume and increasing hemoglobin count was better than traditional Chinese medicine group and western medicine group obviously.(2)The patients of traditional Chinese medicine group had no obvious discomfort during treatment with this medicine. Two patients of Western medicine group appeared mild nausea in early lines of medication, and the symptoms disappeared without treatment. Three patients'weight of Western medicine group increased slightly. One patient's weight increases slightly in integrated traditional Chinese and western medicine group. All patients of integrated traditional Chinese and western medicine group and Western medicine group had different degrees of menstrual decrease during the medicine treatment,7 cases in which appeared menstruation ceasing. There were 5 patients whose thransaminase rised slightly and resumed without treatment soon.(3) There are 43 patients followed up after a period of treatment and its follow-up rate was 96%. The seven patients whose menstruation ceased resumed normal after in 25 days-30 days when drug was Withdrew. The liver and kidney function testing of all patients of integrated traditional Chinese and western medicine group and Western medicine group showed no obvious abnormalities. Ten patients'fibroid volume were reduced after treatment in the traditional Chinese medicine group, another four cases have no obvious change,14 patients'hemoglobin content had no obvious change or rised slightly. There are 9 patients' fibroid volumes smaller after the treatment in western medicine group, another 2 patients'fibroid volume had no change after the treatment.2 patients'hemoglobin content decreased slightly in western medicine group, but were still higher than the level before treatment, the others'hemoglobin content had no obvious change or rised slightly. 13 patients'fibroid volume were reduced of integrated traditional Chinese and western medicine group, another 2 cases had no obvious change, and 15 patients' hemoglobin content had no obvious change or rised slightly. The long-term outcome of integrated traditional Chinese and western medicine group and traditional Chinese group is better than western medicine group.ConclusionThe curative effect of Julisanjie tablet(The patients take it 4 slices 3 times a day) joint small doses mifepristone (The patients take it 5mg twice a week) in treating uterine myoma is excellent, it has little side effects and satisfactory long-term outcome.