Association Of The Levels Of Serum OPG And STRAIL In Patients With Coronary Atherosclerosis Disease

Objective: To investigate association of the levels of serum Osteoprotegerin (OPG) and soluble tumour necrosis factor-related apotosis inducing ligand (sTRAIL) in patients with coronary atherosclerosis disease (CAD).Method: 92 patients were underwent coronary angiography (CAG). The numbers of diseased vessels and stenosis integral calculus were used to represent the severity of CAD. Serum OPG and sTRAIL levels were measured by enzyme linked immunosorbent assay ELISA .Result: Serum OPG levels pg/ml were 1118.7±67.9, 1451.3±297.9, 1801.5±533.2 and 3066.9±552.5 in patients with normal coronary arteries, 1-vessel disease,2-vessel disease and 3-vessel disease respectively, Serum sTRAIL levelspg/ml were 71.3±31.0, 106.4±27.6, 120.0±49.0 and 172.2±28.1 for the subjects with normal coronary arteries,1-vessel disease,2-vessel disease and 3-vessel disease respectively. The levels of serum OPG and sTRAIL were significantly greater in patients with significant stenosis of the coronary arteries than those in patients without stenosis p 0.05 . Multivariate logistic regression analysis revealed that serum OPG and total cholesterol (TC) levels and age were significantly associated with the presence of CAD. Serum OPG and TC and age are the independent risk factors of cardiovascular disease.Conclusions: 1.Serum OPG and sTRAIL levels are associated with the CAD and the severity of coronary stenosis. 2.Serum OPG level increased is the independent risk factor of CAD. Increased serum OPG levels may be a compensatory self-defensive response to the increased serum sTRAIL levels. 3.Serum OPG and sTRAIL levels may be the reference standard of the severity of coronary stenosis.