Application Of Thrombelastogram Monitoring In Patients With Severe Thrombocytopenia

Objective: To study the relationship between thrombelastography variables and hemorrhage in patients with severe thrombocytopenia (PLT≤20×109/L).Mehtods: According to clinical diagnosis, 108 patients whose thrombocytes were no more than 20×109/L, were devided into bleeding group and non-bleeding group. Then we compare them with the results of platelet count and Thrombelastography.Results: In the patients with severe thrombocytopenia, the study showed that there was no significant differences between the two groups about their gender, age, the types of thrombocytopenia, PT, APTT, TT, Fib and partial parameters of thrombelastograph, including R, K, ANGLE, CI, LY30(P>0.05). However the hemorrhage group's platelet count and MA are obviously lower than the non-hemorrhage group's(P<0.05). Resulting form Logistic regression analysis and ROC study, we get bleeding equal to 1.253-0.13PLT-0.042MA, whose cut off point is -1.4785, sensitivity is 0.667, and specificity is 0.833. If the patients' point is higher than -1.4785,93.3% of them will bleed. Conclusion: MA, one variable of thrombelastography, is helpful in predicting bleeding in patients with severe cthrombocytopenia.