Serum SCD40L Concentration And Insulin Resistance In Patients With Coronary Heart Disease

Objective: To understand the correlation between serum sCD40L concentration and insulin resistance in patients with coronary heart disease (CHD).Methods: The patients of CHD (39 cases) were selected as case groups, while the patients of non-CHD (22 cases) were selected as control group. Serum sCD40L, fasting blood glucose, fasting insulin, blood lipid were tested for each subject, and homeostasis mode1 assessment of insulin resistance (HOMA-IR) was calculated.Results: Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) concentration of CHD group showed no significant difference comparing with non-CHD group (P﹥0.05). High density lipoprotein cholesterol (HDL-C) concentration of CHD group was significantly lower than non-CHD group (P﹤0.05). Serum sCD40L concentrations, fasting insulin, HOMA-IR of CHD group was significantly higher than non-CHD group (P﹤0.05). According to the data of CHD group, there existed positive correlation between serum sCD40L concentration and HOMA-IR, fasting insulin, TG, TC, LDL-C (P﹤0.05) , while there existed positive correlation between serum sCD40L and HDL-C (P﹤0.05).Conclusion: The elevation of serum sCD40L levels in patients with coronary heart disease coexisted with insulin resistance. Both factors play a very important role in the development of CHD and diabetes mellitus.