Reropective Study Of Secondary Thrombocytosis In Pediatric Patients

Objective: To investigate the incidence of etiological causes and clinical course of secondary thrombocytosis in pediatric patients, and to estimate the number of platelet count and the other components of blood routine test in the secondary thrombocytosis patients.Methods: All secondary thrombocytosis patients those admitted at Children Hospital of Chongqing Medical University from March 2001 to March 2010 were included in the study. The result categorized by the gender, age, length of hospitalization, clinical symptoms, and laboratory examination result. The results were analyzed with SPSS 17.0 statistical software by using Pearson Chi-Square test, and multivariate statistic. Finding was considered statistically significant if the P value < 0.05.Results: A total of 158 hospitalized patients with secondary thrombocytosis as a main diagnosis (defined as PLT count≥400×109/L) admitted from many departments in Children Hospital of Chongqing Medical University, from March 2001 to March 2010, a total of nine years study. There was a predominant of male group towards female group (sex ratio M:F = 1.3:1). Infants and young children (< 2 years old) were most common group, contributing 81% of total cases. Infections were the most common cause contributing 77.8%, especially from respiratory infections (upper and lower, bacterial and viral). There were 5 patients with Kawasaki disease diagnosis, contributing 3.2% of total cases. Meanwhile, malignancy and post-chemotherapy patients were contributing 3.8% of this study. Most of the patient had good prognosis, without any of these patients developed into thrombotic complication.Conclusions: This study showed infection as the main cause of the thrombocytosis in pediatric patients. Especially, pneumonia from respiratory tract infection was evaluating 25% of all cases. Primary thrombocytosis is rare in pediatric patients. Secondary thrombocytosis is a benign disease and more common in pediatric patients. Patients with secondary thrombocytosis had not specific symptom as primary thrombocytosis, such as hepato-splenomegaly, bruising and bleeding tendency. None of the cases developed into more serious complications, such thrombotic and/or hemorrhagic complications are highly exceptional. Platelet counts were recovered to the normal range after the underlying condition healed.