Correlations Analysis Of Child-Pugh Classification Of Liver Function And Therapeutic Effects And Prognosis Of Endoscopic Variceal Ligation

Objective :To explore the correlation of Child-pugh classification of liver function and the therapeutic effects and prognosis of endoscopic variceal ligation(EVL) procedures performed in patients with liver cirrhosis.Methods :Medical records and follow-up datas of 213 patients with liver cirrhosis undergone EVL operation and 145 patients without EVL operation were analysed.COX proportional hazards regression model was empolyed to analyze the factors affecting patients'survival, Kaplan-Meier(K-M) method was used to estimate and compare the survival rate of patients at different Child-pugh grades.Results :A total of 156 patients completed eradication of esophageal varices procedure.Recurrence rates of varicose vein of patients at grade A,B and C of liver function were 15.2%,30.8% and 53.3%,respectively, with significant defference between C and A or B(P <0.05), and no significant difference between A and B(P >0.05). Their recurrence rate of hemorrhage were 3.0%,5.1% and 8.9%,respectively, from which no significant defferences were found among them ( P >0.05 ) .5-year cumulative survival rates for patients at grade A,B,C in EVL group and control group were 82.79%, 54.94%, 28.71% and 73.2%, 29.7%, 18.2%, respectively, which was statistically significant using pairwise comparison of their survival curves(P <0.05)in the two groups.The survival curves at grade B and C in EVL group were significant different from those in control group(P <0.05).Conclusion :Child-pugh classification of liver function is closely related to varicose vein recurrence rate and patients survival rate after EVL.When liver function is worse, the recurrence rate of varicose vein is higher, and the survival rate is lower. In addition, EVL may improve the long-term survival of patients with liver cirrhosis and esophageal varices.