Pharmacokinetics Of Emtricitabine In The Population Of Western China

Emtricitabine is a new type of nucleoside reverse transcriptase inhibitor,producted by the U.S. company Gilead Sciences,with against hepatitis B virus and human immunodeficiency. Its chemcial constitution is different from other nucleoside reverse transcriptase inhibitor by the fluoro of the 5 carbon position. The mechanism of action of FTC is similar to LAM.But FTC has a longer plasma half-life,and better antiviral activity by the LAM. Its antiviral activity of lamivudine is 4-10 times.And FTC is less toxic,better efficacy and safety than LAM, especially for children.Phaseâ… clinical trial of domestic show that oral administration of emtricitabine is rapidly absorbed in the body. 5'-triphosphate formed by the phosphorylation activity of multi-step. 5 - triphosphate with the natural 5 - phosphate cytosine competition into the process of viral DNA synthesis, leading to viral DNA strand breaks, through competitive inhibition of production of anti-viral activity.The experiment set up an accurate,sensitive method to assay Emtricitabine in plasma,and study the Pharmacokinetics of Emtricitabine in the population of western China.Which provides related reference to rational administration in PrEP for the population of western China. Part 1: Set up an HPLC-UV method to assay Emtricitabine in plasma.Part 2: Study the Pharmacokinetics of Emtricitabine.