The Clinical Evaluation Research On The Program Of Intervening Sub-Health State With Flicking And Poking Along Bladder Channels And Optimizing Plan

Objection:To observe the efficacy of conventional manipulation, flicking and poking along bladder channels and the optimizing plan in intervening sub-health state and estimate the efficacy, effect difference and safety of the three methods above, and to extend application of methods flicking and poking along bladder channels and the optimizing plan.Methods:Multi-centered, stratified randomized and parallel controlled clinical research methods were adopted in this study.360 subjects with sub-health status from three trial center were randomly divided into traditional group, flicking and poking group, and optimizing group with 120 cases in each group. Intervened by conventional manipulation, flicking and poking along bladder channels and optimizing plan, the changes of clinical symptoms, erythrocyte sedimentation rate, plasma lactate, and whole blood viscosity (shear rates of 1.00,5.00,30.00,200.00 s-1), P3b-P3a Amplitude, P3a Latency as well as the efficacy, efficacy difference, safety and quality control were observed.Results:A total of 305 patients completed the trial, (1)The indexes observed before and after trial in treatment group of each center, the whole of each center, all subjects of treatment group was significantly different (P=0.000). (2)After the intervention, the clinical symptom score, erythrocyte sedimentation rate, plasma lactate, and whole blood viscosity (shear rates of 1.00,5.00 s-1),P3b-P3a Amplitude, P3a Latency of the conventional manipulation,the flicking and poking group and the combining group were significantly different from those of before intervention (P＜0.050), the clinical symptom score, erythrocyte sedimentation rate, plasma lactate, and whole blood viscosity (shear rates of 1.00,5.00 s-1),P3b-P3a Amplitude, P3a Latency of the flicking and poking group and the combining group were not significantly different from those of before intervention. The erythrocyte sedimentation rate, and whole blood viscosity (shear rates of 30.00,200.00 s-1) in each group were statistically different from those of before intervention (P<0.050). (3)The adverse reaction in each group were not statistically different (P>0.050). (4)The index of the treatment group subjects intervened by the same treatment in each center were not statistically different form before the intervention (P>0.050).Conclusion:Method of flicking and poking along bladder channels and optimizing plan are safe and effect, the same as methods of conventional manipulation. But flicking and poking along bladder channels and optimizing plan are better, result of two method are differential, so we chose different intervention rationally accord to different clinic symptoms.