Prognostic Significance Of Tumor Size In T3 Gastric Cancer

Objective To investigate the impact of tumor size on the prognosis of patients with T3 gastric cancer.Methods D2 curative resection was performed on 408 patients with T3 Gastric Cancer. Cox proportional hazards model was used to find the optimal critical point of tumor size. Potential prognostic factors were evaluated by univariate and multivariate analysis for all patients, while multivariate analysis was performed evaluating the prognostic factors for the large size group and the small size group.Results Among 408 patients with T3 Gastric Cancer, COX proportional hazards model showed that 8cm is the optimal critical point of tumor size,85 patients with tumor size≥8cm (large size group), while 323 patients with tumor size <8cm (small size group); the 5-year survival rate was 33.8% for the large size group and 52.2% for the small size group, with statistical significance (P<0.05). COX proportional hazards model showed that lymph node metastasis, tumor size and Borrmann type were independent prognostic factors for all patients. Borrmann type IV and N2-3 nodal were independent prognostic factors for large size group. lymph node metastasis was independent prognostic factor for small size group.Conclusions Tumor size is an independent prognostic factor of patients with T3 Gastric Cancer. lymph node metastasis can be used to judge the prognosis of patients with tumor size≥8cm or tumor size <8cm , besides Borrmann type also do some help for determining the prognosis in patients with tumor size≥8cm.