| Objective:By the analysis of the soup square of "Xiexin Decoction" from treatise on febrile disease wrote by Zhang Zhongjing, we want to reveal the connotation of the theory of "pungent open bitter drop" of Zhang Zhongjing and expand its clinical application.Methods:Based on the Knowledge Element semantic analysis, we deconstructed the Knowledge Element of traditional Chinese herbs in the aspects of character and efficacy. With the compatibilities of Knowledge Element of Five Taste, property and flavor, property and efficacy, "effect-differentiation-symptom-disease " structured association and "effect-effect" Knowledge Element structured association and other intellectual Element structured, we established the analysis model of Chinese compound formula linking to Knowledge Element, thus to analysis compatibility of herbal medicinal properties and its expression of Knowledge Element compatibility effect analysis. We use this model to elaborate the process of the compatibility, expression and efficacy of herbs in Xiexin Decoction party and illustrate the applications and evolution according to the differentiation. On the aspects of indications, syndrome model, the commonly used medicine and drug analysis, clinical reagent train of thought we explained the Zhang Zhongjing " pungent open bitter drop" clinical reagent method. And we also extended the " pungent open bitter drop " clinical reagent use by using mild herbs compatibilitLy,pungent cold and pungent cool herbs compatibility and the flexible compatibility of the herbs. Results:1.The content of the theory of "Pungent open bitter drop" of ZhangZhongJing1.1 The medicine characters of the theory of "Pungent open bitter drop" of Zhang ZhongJingGas Knowledge Element:Cold+Hot; cold+warm; cold+hot (Choose 1 from the 3); five flavors knowledge element:bitter, pungent; "pungent" Herbs:hot, warm, extremely hot (Choose 1 from 3); "bitter"herbs:cold.1.2 The accommodative disease cause of the theory of "Pungent open bitter drop" of ZhangZhongJingExternal cause:wind, cold, summer heat, wet, dry, fire, heat Internal cause:worm, poison, food, Ji, Nong, Jie.1.3 the mechanism of the accommodative disease of the theory of "Pungent open bitter drop" of Zhang ZhongJingThe soup square of "xiexin decoction" attended the diseases with pathogenesis of mixture of Biao Li,Xu Shi,cold and heat. The mixture of Biao Li refers to the Biao and Li with the disease; The mixture of Xu Shi refers to the Xu to Shi,Shi to Xu,Xu and Shi with the disease; Xu refers to the yang deficiency,qi deficiency,blood deficiency,jin deficiency,spleen and kidney deficiency, Shi refers to the hot or cold of the heart,liver,gallbladder,lung,sputum,wet,water,drinking, air stagnation,gas inverse,blood stasis,insects card,drug card,node card,septic permit. The mixture of hot and cold refers to the hot under the cold,the cold under the hot,or the hot in the form of cold.1.4 The specific meaning of the "pungent open bitter drop" of Zhang Zhongjing in the different and dialectical systemIn "the eight principles of dialectical efficacy", "pungent open" means: scattered cold,zhu yang,hui yang,tong yang,fa biao; "bitter drop " means:qing re,qian yang,yang yin;In "the internal and external cause of dialectical efficacy", "pungent open" means:qu feng,scattered cold,jie shu,xiaoshi; " bitter drop " means:qin re,xie huo,xi feng;In "the qi-blood-body fluid of dialectical efficacy", "pungent open" means:xing qi,huo xue,hua yu,chu si,hua tang; "bitter drop" means:jiang qi,liang xue,zhi xue,xue shui,zhu yin; In "the organs of dialectical efficacy", "pungent open" means:wen fei,xuan fei,tong yang,shu gang,wen zhong,tiao zhong; " bitter drop " means:qin fei,tong chang,qin xin,qin gang,pin gang,li dang;1.5 The syndrome that the Recipe of the theory of "Pungent open bitter drop" of Zhang ZhongJing is involved(1)The deficiency of the exterior (the main syndrome):the syndrome of the deficiency of the external yang(2)The excess of the exterior (the minor syndrome):the syndrome of the excess of the external cold(3)The deficiency of the interior (the minor syndrome):the syndrome of the deficiency of the internal yang, the syndrome of the deficiency of the internal yin; the syndrome of the deficiency of qi,the syndrome of the deficiency of blood,the syndrome of the deficiency of jin;the syndrome of the deficiency of the spleen and kidney(4)The excess of the interior (the main syndrome):The syndrome of the excess of the internal hot——the syndrome of the hot of the blood,the syndrome of the hot of the phlegm,wet,water and drink; the syndrome of the hot blocking up the lung, the syndrome of the hot and phlegm blocking up the lung, the syndrome of the hot and damp blocking up the intestine the syndrome of the hot and phlegm blocking up the heart, the syndrome of the hot and phlegm blocking up the heart; the syndrome of the hot blocking up the liver and gall, the syndrome of the hot and damp blocking up the liver and gall; the syndrome of the hot and damp blocking up the spleen, the syndrome of the hot blocking up the stomach;The syndrome of the excess of the internal cold——the syndrome of the cold of the phlegm,wet,water and drink; the syndrome of the cold blocking up the lung, the syndrome of the damp and phlegm blocking up the lung; the syndrome of the cold blocking up the heart; the syndrome of the cold and damp blocking up the spleen, the syndrome of the cold blocking up the stomach;The else syndrome of the internal excess——the syndrome of the air inverse, the syndrome of the air stagnation; the syndrome of the blood stasis; the syndrome of the food injury,the syndrome of the insects,the syndrome of the drug,the syndrome of the node,the syndrome of the septic,the syndrome of the permit; the syndrome of the air stagnation of the liver,the syndrome of the air stagnation of the gall and the phlegm blocking up the gall,the syndrome of the phlegm blocking up the heart1.6 The accommodative model of the syndrome of the theory of "Pungent open bitter drop" of Zhang ZhongJing(1) the syndrome of the deficiency of the exterior+the syndrome of the excess of the interior; (2) the syndrome of the excess of the interior+the syndrome of the excess of the interior; (3) the syndrome of the deficiency of the interior +the syndrome of the excess of the interior; (4) the syndrome of the deficiency of the exterior+the syndrome of the excess of the interior+the syndrome of the excess of the interior; (5) the syndrome of the deficiency of the exterior +the syndrome of the deficiency of the interior+the syndrome of the excess of the interior; (6) the syndrome of the excess of the interior+the syndrome of the deficiency of the interior+the syndrome of the excess of the interior; (7) the syndrome of the deficiency of the exterior+the syndrome of the excess of the interior+the syndrome of the deficiency of the interior +the syndrome of the excess of the interior.2. The clinical application of the theory of "Pungent open bitter drop" of Zhang Zhongjing2.1 The clinical analysis of the soup square of "Xiexin Decoction" analyze The syndrome on dialectical level of the eight principles of dialectic,the internal and external cause of dialectic,the qi-blood-body fluid of dialectic and the organs of dialectic, which the Recipe of the theory of "Pungent open bitter drop" of Zhang ZhongJing is involved, and summarize the adapt syndromes of each square.According to the role of various medicinal properties'element in the Recipe of the theory of "Pungent open bitter drop" of Zhang ZhongJing, compare the soup square of " Xiexin Decoction " of different parties and provide theoretical basis for clinical use.2.2 The evolution of the soup square of "Xiexin Decoction"State the recipe of the soup square of "Xiexin Decoction" how to select the medicine square with syndrome weight changed, and explain how to convert by square by adding and subtracting medicine gradually from the Purging of lateral heart soup,Dry ginger radix scutellariae coptis ginseng soup,Banxia xiexin decoction. Licorice purging heart soup. Ginger purging heart soup,rhizoma coptidis decoction to the Overburden and spin germick soup.2.3 The clinical reagent method the theory of "pungent open bitter drop" of Zhang ZhongjingOn the aspects of indications, syndrome model, the commonly used medicine and drug analysis, clinical reagent train of thought we explained the Zhang Zhongjing " pungent open bitter drop" clinical reagent method. The method is: one, judge patient's syndrome; Second, select medicine by basing on syndrome weight; Three, formula by basing on syndrome models.2.4 The extend of the clinical reagent use of the theory of "pungent open bitter drop" of Zhang ZhongjingAnd we also extended the " Pungent open bitter drop " clinical reagent use by using mild herbs compatibility, pungent cold and pungent cool herbs compatibility and the flexible compatibility of the herbs.Conclusion:Basing on the semantic analysis of the knowledge element to construct the model with the reconstitution of the knowledge element about the Chinese herbal property, we can reveal the logic relation between the medicine and compound about the Chinese herbal property and effect, and betterly clarify the process of the way from single herb to the efficacy expression of the compound, and analyze the compound of TCM on dialectical level of the eight principles of dialectic,the internal and external cause of dialectic,the qi-blood-body fluid of dialectic and the organs of dialectic, so as to betterly mine the connotation of the the theory of "Pungent open bitter drop" of Zhang Zhongjing. And we also extended the " Pungent open bitter drop clinical reagent use by using mild herbs compatibilitly, pungent cold and pungent cool herbs compatibility and the flexible compatibility of the herbs. |
