Relations On The Contents Of Serum MMP-9 And SFas In The Serum Of Pregnant Women And Onset Of Labor

Objectives:through the detection of the contents of serum soluble Fas molecule (sFas) and matrix metalloproteinase-9 (MMP-9) in serum of pregnant women, explore the role of soluble Fas molecules and matrix metalloproteinases-9 in preterm delivery and onset of labor,and investigate the relevance between the two factors.Methods:20 cases with preterm delivery with labor (the experimental group-1),20 cases with over 28 weeks but Less than 37 weeks gestation without labor (the control group-1),20 cases of term pregnancy with labor(the experimental group-2),20 cases of term pregnancy without labor (the control group-2) were studied. The contents of MMP-9 and sFas in the maternal serum of vein blood were determinded by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). The experimental data was processed by Statistical Package with SPSS17.0.Results:1,The average contents of MMP-9 in the experimental group-1,the control group-1,the experimental group-2 and the control group-2 were respectively (454.03±42.97)ng/L,(222.94±29.04)ng/L,(471.70±33.35)ng/L,(256.62±45.80) ng/L.Groups were compared.There were statistically significant differences between the experimental group-1 and the control group-1 or the experimental group-2 and the control group-2(P<0.001). There were no statistically significant differences between the the experimental group-1 and the experimental group-2 or the control group-1 and the control group-2(P>0.05).2,The average contents of sFas in the experimental group-1,the control group-1,the experimental group-2 and the control group-2 were respectively (1319.17±32.89) ng/L,(676.15±23.65) ng/L,(1260.59±109.36) ng/L (764.39±46.11) ng/L.Groups were compared. There were statistically significant differences between the experimental group-1 and the control group-1 or the experimental group-2 and the control group-2(P<0.001). There were no statistically significant differences between the experimental group-1 and the experimental group-2 or the control group-1 and the control group-2(P>0.05).3,The level of MMP-9 and sFas in maternal serum in preterm birth is positive correlation (Pearson correlation coefficient r=0.871, P<0.001). The level of MMP-9 and sFas in maternal serum in term delivery is also positive correlation (Pearson correlation coefficient r=0.817, P<0.001).Conclusions:1,The level of MMP-9 in maternal serum in labor group(the group of preterm delivery with labor and the group of term pregnancy with labor) is significantly higher than that in without labor group(the group of over 28 weeks but Less than 37 weeks gestation without labor and the group of term pregnancy without labor). There were no statistically significant differences between the experimental group-1 and the experimental group-2. The level of MMP-9 increased in maternal serum may be related with the delivery launch (pre-term or term labor),and may be unrelated with gestational week.2,The level of sFas in maternal serum in labor group(the group of preterm delivery with labor and the group of term pregnancy with labor) is significantly higher than that in without labor group(the group of over 28 weeks but Less than 37 weeks gestation without labor and the group of term pregnancy without labor). There were no statistically significant differences between the experimental group-1 and the experimental group-2. The level of sFas increased in maternal serum may be related with the delivery launch (pre-term or term labor),and may be unrelated with gestational week. 3,There is a positive correlation between the level of MMP-9 and sFas in maternal serum in the onset of labor.