Correlation Of Regulatory T Cells And NKG2D-expressing NK Cells In Patients With Lung Cancer And Clinical Significance

Objective The aim of the study is to detect the levels of CD4⁺CD25^HiCD127 ^Lo regulatory T cells and NKG2D-expressing NK cells in peripheral blood of lung cancer, and investigate their relationship, and explore their role in the immune escape of lung cancer and clinical significance.Method The levels of CD4+CD25HiCD127LoTreg cells,NK cells and NKG2D-expressing NK cells were measured in peripheral blood of 70 lung cancer patients and 50 healthy controls.Results Compared with control group, the levels of CD4+CD25HiCD127Lo Treg cells enormously increased(P<0.05), while the value of NKG2D obviously decreased(P<0.05);And the group of NK cells is not different(P>0.05);NKG2D-expressing NK cells had a perfect negative correlation with CD4+CD25HiCD127Lo Treg cells ( r=-0.302, P<0.05).Conclusions Accumulation of Treg cells in serum may lead to the down-modulation of NKG2D-expressing NK which participates the tumor immune escape . They may be potential indicators evaluating immune functions .