Clinical Analysis Of 103 Langerhans Cell Histiocytosis Cases

Objective:To analyze and discuss the clinical manifestation, diagnosis, treatment methods, outcomes and follow up of Langerhans cell histiocytosis (LCH)Methods:A retrospective analysis was carried out among 114 LCH patients who were admitted to the First Affiliated Hospital of Guangxi Medical University from Jan.2000 to Nov.2010.The data including gender, age, clinical manifestation, diagnosis, treatment regimen, outcome and follow up.Results:One hundred and three patients comply with the standard of the classification outline which was written by group of the histiocyte society in 1987. In the 103 patients,13 patients were<2 years,28 patients were～5 years,28 patients were～15 years,34 patients were≥15 years, including 64 males and 39 females(M:F ratio,1.64:1). Seventy-nine patients were the Single System LCH (SS-LCH) and 24 patients were the multisystem LCH (MS-LCH). In SS-LCH,70 patients were gradeⅠ,9 were gradeⅡ, and none was gradeⅢandⅣ; and in MS-LCH,7 patients were gradeⅠ,8 were gradeⅡ,4 were gradeⅢ, 5 were gradeⅣ. The most lesion was bone in LCH. Frequently, surgery was adopted in SS-LCH, and combined chemotherapy was adopted in MS-LCH. Through treatments, in SS-LCH,76 patients were better,2 were worse; and in MS-LCH,10 were better,2 were intermediate,5 were worse. Forty-eight patients were followed up, which 37 were better,6 relapsed,6 dead,1 was found malignant lymphoma and 2 were found sequelae. Fifty-five patients lost of follow up.Conclusion:(1) The LCH is affected to happening in the period of child. (2) SS-LCH was more common than MS-LCH, and the most lesion was bone in LCH. (3) Radiological examination was significant for finding LCH early. (4) Surgery was adopted in SS-LCH, and combined chemotherapy was adopted in MS-LCH frequently. (5) The outcome of SS-LCH was better than MS-LCH.