ObjectiveTo evaluate efficacy and toxicity of concurrent chemotherapy and radiotherapy for locally advanced esophageal carcinoma patients.MethodsOne hundred and six cases were treated with docetaxel, nedaplain and fluorofur with concurrent radiotherapy for locally advanced esophageal cancer. A (concurrent radiotherapy and chemotherapy, CCRT) chemotherapy:docetaxe 50mg/m2, d1, iv+ nedaplain 60mg, d1-3,iv+fluorofur 1g, d1-3, iv, w1,5,8,11; 3DCRT/IMRT: 60-66Gy/7-7.5w. B (radiotherapy alone 3DCRT/IMRT) 3DCRT/IMRT: 60-66Gy/7-7.5w.ResultsAll of the patients finished the CCRT and 3DCRT/IMRT. In 56 patients of A, 87.5%(49/56) of the overall response rate was observed, In 50 patients of B,64%(32/50) of the overall response rate was observed.Conclusiondocetaxel, nedaplain and fluorofur combined with concurrent radiotherapy for locally advanced esophageal cancer is effective and well-tolerated in patients with locally advanced esophageal cancer.
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