The Expression Of STAT3 And PIAS3 In Salivary Gland Tumor

Objective:STAT(signal of transducer and activators transcription) is a factor which can mediate the signal of cell factors and growth factors into nuclear. It can not only affect the transcription of target genes, but also regulate the function of cell. One of the important members of STAT is STAT3, which showed a high level of activation status in many types of human tumors.PIAS3 (Protein inhibitor of activated signal transducer and activator of transcription 3) is an inhibitory factor of STAT3, which can stop the combination of pSTAT3 and DNA. The researches showed that PIAS3 widely distributed in human malignant tumors.Salivary gland tumor is a kind of universal oral tumor, but the expressions of STAT3 and PIAS3 are rarely reported. This research is to study the expression of STAT3 and PIAS3 in salivary gland tumor.Methods:The expression of STAT3 and PIAS3 in salivary gland tumor and normal salivary gland tissues were detected by immunohistochemical assay,the automatic image analyzer was used to analyze the gray scale of the STAT3 and PIAS3.Results:(1)The positive rate of expression of STAT3 was significantly higher (p<0.05) in the group of malignant salivary gland tumor than in the group of benign salivary gland tumor,while the group of benign salivary gland was significantly higher (p<0.05) than that in normal salivary tissue.(2)The positive rate of expression of PIAS3 was significantly higher (p<0.05) in the group of malignant salivary gland tumor than in the group of benign salivary gland tumor,while the group of benign salivary gland was significantly higher (p<0.05) than that in normal salivary tissue.(3)The expression of STAT3 was positively correlated with the expression of PIAS3 in the salivary gland tumor (p<0.05) .Conclusion:The expressions of STAT3 and PIAS3 are closely related to the degree of malignance in salivary gland tumor. STAT3 and PIAS3 play an important role in the pathogenesis and development of salivary gland tumor, from which we could find a new way to treat salivary gland tumor in the further work.