| Objective: To evaluate the therapeutic effect of administration ofω-3 Polyunsaturated fatty acids and the possibility of C-reactive protein(CRP) as an index for estimating the effect ofω-3 Polyunsaturated fatty acids in the patients with severe traumatic brain injury,and to provide the experimental evidence for administration ofω-3 Polyunsaturated fatty acids in the patients with severe traumatic brain injury. Methods: Seventy patients who inter our hospital in July -September 2010 with severe brain injury were randomized into two groups(treatment group and control group) : every group includes 35 patients.All the patients who were enrolled within 12 hours after injury.Inclusion criteria included that all patients were 18～60 years old and had head injury history;there were indeed traumatic brain injury.Patients were excluded for the following reasons:associated with severe injury on other parts of body;renal insufficiency;metabolic diseases;severe diseases on important organ of body. Control group administration of surgery, bleeding, dehydration, reduced intracranial pressure, nerve nutrition, protect the gastric mucosa and other conventional treatment, In the treatment group,clinical management principles were the same as control group exceptω-3 Polyunsaturated fatty acids(2ml/kg/d). The serum concentration of CRP of all patients were monitored at 1stday,4thday,10th day;All of these data were analysed by SPSS 12.0 statistics sofware,P value of less than 0.05 were considered to indicate statistical significance.All of these data were analysed by SPSS 12.0 statistics software,P value of less than 0.05 were considered to indicate statistical significance.Results:①Before treatment(the first day),serum CRP was (75.54±7.83)mg/L in the treatment group,and (71.23±9.21)mg/L in control group,showing no significant difference between two groups (P>0.05).②After treatmen(the fourth day),serum CRP was(50.34±7.03)mg/L in the treatment group,and(53.69±8.17)mg/L in control group,showing a significant difference between two groups (P>0.05).③After treatmen(the tenth day),serum CRP was (35.25±10.09)mg/L in the treatment group,and (48.36±13.11)mg/L in control group,showing a significant difference between two groups (P>0.05).④After ten days,serum CRP both in two groups were significantly lower than before treatment.the difference was (40.29±8.02)mg/L in the treatment group, showing a significant difference between before treatment and after treatment (p>0.05).⑤serum CRP in various types of patients were significantly higher than Normal, after treatment, serum CRP were significantly lower than before treatment. both before and after treatment, serum CRP were the highest is in particularly severe patients, were higher in heavily patients,and the lowest is in medium patients.Conclusion:ω-3 Polyunsaturated fatty acids administration provides an effective therapy for traumatic brain injury.CRP can serve as an index for estimating the degree of traumatic brain injury and the effectiveness ofω-3 Polyunsaturated fatty acids treatment.
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