Relationship Between Serous Expression Of ALT, AST, HBVM And Hepatic Pathologic Impairment Of Patients With Chronic HBV Carriers Infection

Objective To analyze the pathological features of Liver and the correlation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), Hepatitis B virus markers with the Liver pathology in patients with hepatitis B virus carriersMethods 50 patients with chronic hepatitis B virus(HBV) carriers, 21 patients with Inactive HBsAg carriers and 20 patients with chronic hepatitis B(which ALT level is 40-80U/L)(Mild chronic hepatitis B) were enrolled in this study.The Serum HBV markers, Liver function and HBV-DNA were detected. Liver biopsies were performed at the same time in all patients and histological grade and stage were evaluated. The relationship between the serum ALT, AST,HBeAg,HBV-DNA and the Liver pathology were analyzed.Results 1. Of 50 patients with chronic HBV carriers, there were 13(26%),26(52%)and 11(22%) cases belong to GO, G1 and G2-4 respectively,23(46%),16(32%) andll(22%) cases belong to SO, S1 and S2-4 respectively. Of 21 patients with Inactive HBsAg carriers, there were 9(42.5%), 11(52.4%)and 1(4.7%) cases belong to GO, G1 and G2-4 respectively,11(52.4%),9(42.9%) and 1(4.7%) cases belong to S0, S1 and S2-4 respectively. Of 20 patients with chronic hepatitis B, there were 5(25%),8(40%)and 7(35%) cases belong to GO, G1 and G2-4 respectively,8(40%),6(30%) and 6(30%) cases belong to SO, S1 and S2-4 respectively.There was no statistical differences in the grades of inflammation and fibrosis between both chronic HBV carriers and Inactive HBsAg carriers group and chronic HBV carriers and Mild chronic hepatitis B group.2.The degree of liver inflammation and fibrosis GO-4 SO-40,1,2,3,4points were calculated, Calculation of three groups with liver inflammation and fibrosis of the mean. Inflammation of the mean G with chronic HBV carriers is (1.02±0.845),and for the Inactive HBsAg carriers group Is (0.62±0.59), Mild chronic hepatitis B group is (1.15±0.875),There was significantly difference in the Inflammation of the mean G between Chronic HBV carriers group and Inactive HBsAg carriers group (P<0.05),but There was no significantly difference between the Chronic HBV carriers group and the Mild chronic hepatitis B group(P>0.05).And the mean S with Chronic HBV carriers group is (0.52±0.602),and for the Inactive HBsAg carriers group is (0.52±0.602), Mild chronic hepatitis B group is (1.05±1.099).There was no significantly difference in the mean S both chronic HBV carriers and Inactive HBsAg carriers group and chronic HBV carriers and Mild chronic hepatitis B group(P>0.05).3. There was no significantly relationship between the serum ALT,AST,HBeAg,HBV-DNA and the grades of liver inflammation and fibrosis with the chronic HBV carriers patients.4.Of 34 male patients with chronic HBV carriers. There was no significantly differences in the grades of inflammation and fibrosis between ALT>30u/L group and ALT≤30 u/L group.5 Of 50 patients with chronic HBV carriers,there was significantly deference in the grades of fibrosis between Younger than 40 years group and older than 40 years group,the latter had a high rate of severe fibrosis.Conclusions 1.For the chronic HBV carriers,even if liver function are normal,74% of them also have different degrees of hepatic pathological damage.2. For chronic HBV carriers ALT, AST, HBeAg,HBV-DNA and liver pathological changes are not totally consistent.3. Chronic HBV carriers which aged over 40 should be given antiviral treatment.