Expression And Clinical Significance Of Cyr61,VEGF And HSP27 In Hepatocellular Carcinoma

Objective To investigate the relationship of Cyr61,VEGF and HSP27 with the pathological properties and metastasis of hepatocellular carcinoma (HCC).Methods Expression of Cyr61,VEGF and HSP27 was detected by immunohistochemistry assay(SP) in 34 hepatocellular carcinoma and its paraneoplastic liver tissue.Results The positive expression rate of Cyr61, VEGF and HSP27 was 56%, 59% and 59% in HCC, the expression positive rate of Cyr61, VEGF and HSP27 was82%, 29% and 26% in the para-neoplastic liver tissue. The expression rate of VEGF and HSP27 was significantly higher in HCC than those in the paraneoplastic liver tissue. (P < 0.05), the level of expression of Cyr61 was significantly higher in the paraneoplastic liver tissue than that in HCC (P < 0.05). The positive expression rate of Cyr61, VEGF and HSP27 was 32%, 32% and 35% in HCC with portal vein tumor thrombus infiltration, the level of expression rate was 24%, 27% and 27% in HCC without portal vein tumor thrombus infiltration, the expression rate of Cyr61, VEGF and HSP27 was significantly difference between the two groups (P < 0.05).The positive expression rate of Cyr61,VEGF and HSP27 was 35%, 50% and 4% in HCC with metastasis, the level of expression of Cyr61,VEGF and HSP27 was 21%, 9% and 15% in HCC without metastasis , the expression rate of VEGF and HSP27 was significantly higher in HCC with metastsis than those in HCC without metastsis.(P < 0.05).Conclusions The expressions of Cyr61, VEGF and HSP27 may play an important role in hepatocellular carcinogenesis and be closely related to metastasis of HCC . The expressions of Cyr61, VEGF and HSP27 may have important clinical value in determining metastasis and prognosis of HCC.