Expression Of Ki-67 And Its Relationship With Chemotherapy Treatment Effect In Late Stage Human Nasopharyngeal Carcinoma

Objective:To study the relationship between the expression of Ki-67 and chemotherapy treatment effect in late stage human nasopharyngeal carcinoma, and to explore whether ki-67 can be used as a predictor for chemosensitivity and for prognosis in human breast cancer.Methods:Got the expression of Ki-67 and clinical features from 64 cases of nasopharyngeal carcinoma. The features included age, TNM stage, chemotherapy treatment effect. Analysised the relationships between Ki-67 and the features.And then searched the significance of the Ki-67 for treating and predicting prognosis in nasopharyngeal carcinoma.Results:The positive expression rate of Ki-67 was70.3%in the object. The Ki-67 was not related to age, TNM stage (P>0.05). In the Ki-67 low expresssion group, the overall clinical efficacy of chemotherapy (RR) was88.6%. Accordingly? the Ki-67 high expresssion group was 75.9%. The difference between the two groups shows no statistically significant (P>0.05). In addition, neither in the PF chemotherapy regimen, nor in not PF chemotherapy regimens, there was no significant difference between ki-67 and its correlation to chemotherapy (P value> 0.05). In the Long-term survival, the Ki-67 low expresssion group and the high expression group did not show a survival advantage. Its 1,3 and 5-year survival rate was not higher than the high expression group. The difference was not statistically significant (P> 0.05).Conclusions:In late stage nasopharyngeal carcinoma the expression of Ki-67 was not related to age, TNM stage, chemotherapy treatment effect and survival time. So Ki-67 was not the main sensitive predictors for chemotherapy treatment effect and it was not the main prognosis predictors in late stage human nasopharyngeal carcinoma either.