Effects Of Exercise-Induced Weight Loss On Plasma LPL Activity And Plasma Lipid In Obese Children And Adolescents

Research purposeThe aim of this research is to formulate individualized exercise prescription for the obese children and adolescents before and during exercise-induced weight loss and to supervise in practice. To measure the body shape indicators including body height, body weight, percentage of body fat, waistline, blood biochemical indicators including fasting plasma lipid and plasma LPL activity before and after weight reduction exercise. To find the effects of 4 weeks weight reduction exercise, and also to find what the effects are on plasma lipid and plasma LPL activity and to provide theoretical evidence for research on the method of exercise-induced weight loss.Subjects and methodSubjects:29 obese children and adolescents (male:15, female:14,8-17 yrs) who taking part in the adolescents Summer Sports Camp in Shanghai 2009.Methods:before the study, we investigated the eating habit, exercise habit, medical record, family medical history, hypersusceptibility history and obese history to make sure the subjects were simple obese adolescents. Physique test and exercise load test was made to know the subjects'health condition and exercise capacity and to exclude subjects who suffered from cardiovascular system dysfunction from normal subjects by ECG as well as exercise load test ECG.. Blood biochemical indicators including fasting plasma lipid, plasma LPL activity was obtained before study.We formulated individualized exercise prescription based on the results of the test. Obese children and adolescents took part in 4 weeks weight reduction plan,6 days per week and 5-6 hours everyday by moderate and low-intensity long duration aerobic exercise. Same measurement and test were carried out after 4 weeks. The data have been analyzed by SAS6.12 statistical package in student T test, the correlation between indicators have been analized in linear correlation. It was significantly changed by P <0.01 and obviously changed by P<0.05.Research result1.Body shape indicators change after 4 weeks intervention。The body weight, BMI, percentage of body fat decreased in obese children and adolescents after 4 weeks intervention (highly significant). Body weight decrease 7.56kg for male and 6.08kg for female (decreased 10.13% and 8.39%). BMI decreased 2.93 for male and 2.67 for female. Percentage of body fat decreased 6.57% for male and 6.70% for female. Body fat decreased 6.93kg for male and 7.25kg for female. WC decreased 14.90cm for male and 12.95cm for female (highly significant). HC decreased 9.59cm for male and 8.88cm for femal. Waist hip rate decreased both for male and femal (highly significant). 2. Fasting plasma lipid change after 4 weeks interventionAfter 4 weeks intervention, TG decreased from 1.80mmol/L to 0.67mmol/L for male and from 1.24mmol/L to 0.7mmol/L for female. TC decreased from 5.06mmol/L to 3.50mmol/L for male and from 4.44mmol/L to 3.42mmol/L for female. LDL decreased from 2.90mmol/L to 2.0mmol/L for male and from 2.55mmol/L to 2.0mmol/L for female. There were no significant changes in HDL for male and female although it tended to decrease. LDL/HDL decreased from 2.33 to 1.75 for male and from 2.21 to 1.93 for female (all highly significant).3. The change of fasting plasma LPL activity after 4 weeks intervention.After 4 weeks, the LPL activity increased both in male and female. It increased from 529.34U/L to 612.62U/L for male (highly significant) and from 486.19U/L to 543.18U/L (highly significant).4. The correlation between LPL activity and percentage of body fat, waist circumference and age.LPL activity is negatively related to the percentage of fat both in male and female (highly significant). LPL activity is negatively related to the waist circumference in male and female as a whole (highly significant). LPL activity is negatively related to age in male and female as a whole.Conclusions1. It is utility way to reduce body fat weight and improve the obese children and adolescents'body configuration indicators by moderate and low-intensity exercise.2. It is utility way to increase the LPL activity in blood serum of obese children and adolescents and to promote the hydrolysis of TG in triglyceride rich lipoprotein and then to improve the lipid metabolism of the children and adolescents by moderate and low-intensity exercise.3. LPL activity is negatively related to the degree of abdominal obesity, it exist causal relation between them reciprocally.4. The LPL activity in blood serum of obese children and adolescents will gradually decrease as they grow old, so it is good to carry out weight reduction exercise on earlier period and it will contribute to improve dyslipidemic states on earlier period, and to reduce the incidence rate of MS when they grow up.