Oxygenation Of Peritoneal Ventilation With Oxygen On Rabbits In Asphyxia

Objective:Cardiac arrest was induced with asphyxia to observe the oxygenation of peritoneal ventilation with oxygen in a rabbit asphyxia model and the effect on the duration of the heartbeat from the start of asphyxia to cardiac arrest.Methods:All rabbits were anesthetized by intramuscular injection of ketamine and droperidol, and then the inflow and outflow catheters were placed in the peritoneal cavity for connecting the gas source. The animals were randomized into three groups: control group (no treatment with oxygen, n=8), air group (treated with air, n=8), and oxygen group (treated with oxygen, n=8) in a blinded fashion. At the time of the tracheal catheter clipped the ventilation (with air in air group or oxygen in oxygen group) was administered in time from the inlet in the abdominal wall. Blood gas analysis was performed and mean arterial pressure (MAP) was observed in all groups before clipping the tracheal tube and in every minute after asphyxia.Results:The arterial partial pressure of oxygen increased in both air group and oxygen group, but significantly more in oxygen group (p<0.05). The partial pressure of carbon dioxide decreased significantly after the forth minute of asphyxia compared with the control group (p<0.05). The heartbeat lasted longer time in oxygen group than the other two groups (p<0.05). MAPs were no obviously change in three groups.Conclusion:The arterial partial tension of oxygen can be increased and the partial pressure of carbon dioxide can be decreased at the late period via transperitoneal ventilation with gaseous oxygen. Transperioneal oxygenation can prolong the lasting time of heartbeat.