Improvement Of Anticoagulation Behaviour Of Catheter Via Grafting Copolymerization Of Hydrophilic Monomers

Medical catheter, which is one of the most widely application clinical use medical equipment, but the interrelated questions like thrombus and thrombin aroused by indwelling catheter are very trickiness in clinical therapy. The thrombosis is decided by the number and morphology of adsorption water on the surface of material (in precedence of protein's adsorption). So it can be enhanced the anticoagulant by enhance the surface hydrophilic and lubricity. Otherwise, lubricating surface not only reduce the adsorption of protein and platelet, but also anti-bacterial adsorption, so Prevent wound infection and complications occur.In recent years research results that, as argon, helium and other non-reactive gas atoms can not go directly to the macromolecular polymer chain of surface, but use high-energy particles bombarding the material surface to transfer energy, interacting with the surface of the chemical or physical interaction, and at last form to much peroxy radical. Only plasma treatment also can gain surface hydrophilic of NRL, but it has low durability. To solve this problem, the directly way is graft a amount of durability reactive group onto the material surface, thus it could have the possibility to offer immobilized biological material and improve hydrophilic of material.First of all, this work preparation vulcanized the NRL film according to the standard system of rubber, then modified the surface of pre-vulcanized NRL film by argon plasma pretreatment and a subsequent UV-inducing graft copolymerization with N-vinypyrrolidone (NVP) and hydroxyethyl methacrylate (HEMA), gain surface modification sample, followed by platelet adhesion test. Find the best modification effect of sample. Confirm the best conditions for surface modification via single factor, testing time of plasma treatment and UV irradiation, and select. The surface hydrophilic, element content and structures of resulting nanocomposites are investigated with surface water contact angle, FTIR-ATR, XPS, SEM, AFM, and comparisons were made on graft effect between differ condition of NVP monomer.The results show that grafted the hydrophilic monomer NVP, the graft effect was better in pure monomer solution after soaking the quartz glass caused directly by light than in aqueous solution. And the argon plasma pretreated time was 2 min and the UV irradiation time was 10 min, modification samples was better. For another monomer HEMA, the best condition of modification was argon plasma time 20s and UV inducing time 30min. And the XPS results show that the element content of oxyphilic and nitrogen were significant increased after surface copolymerization; the AFM and SEM results show that the modified NRL film surface with hydrophilic monomer NVP and HEMA were graft copolymer to membrane, formed a rugged hydrophilic coating; and the surface morphology of NRL film after the platelet adhesion experiment the with SEM, the numbers of adhered platelets decreased obviously with graft copolymerization of NVP, indicating the great improvements of hydrophilic and anti-coagulant behaviours of NRL film.