Effect Of Propofol On The Intestinal Permeability And Endotoxin Translocation In Patients Following Hepatectomy

Objective To investigate the effect of propofol on the intestinal permeability and endotoxin translocation in patients following hepatectomyMethods Thirty ASA I-II patients undergoing elective hepatectomy in Pringle method combined with clamping the inferior vena cava below the liver, aged between 38-65 yr, were randomly divided into 2 groups (n=15 each).Ⅰpropofol group received propofol 4～6mg·kg-1·h-1 continuous infusing .Ⅱcontroll group received sodium chloride 4～6mg·kg-1·h-1 continuous infusing during the whole surgical procedures. Blood samples were collected prior to 2,12,24,48h after surgery for plasma D-lactated, and LPS measurement.Results Compared with the preoperation, the plasma levels of D-lactate and LPS in patients 2h after surgery were significantly increased in two groups (P<0.05). Compared with groupⅡ, the plasma levels of D-lactate and LPS in patients significantly decreased in each time after surgery.Conclusion Propofol 4～6mg·kg-1·h-1 by continuous infusing during the whole surgical procedures can decrease intestinal permeability and endotoxin translocation in patients undergoing elective hepatectomy in Pringle method combined with clamping the inferior vena cava below the liver.