Prognostic Factors In Patients With Pancreatic Carcinoma By Multivariate Analysis

Objective:To explore the major prognostic factors in patients with pancreatic carcinoma.Methods:154 patients with pancreatic carcinoma in the last seven years choosed from affiliated union hospital of fujian medical university were reviewed.Survival rate was caculated by Kaplan-Meier estimation while survival cruve was analysed by log-rank test.Prognostic factors were studied by multivariate analysis with COX proportional hazards survival model.Results:In this group,survival time was 1 to 106 months and the median survival time was 8 months.Overall survival rates at months 6,12,18,36 were 58.4%,29.2%,16.3% and 3.7% respectively.Multivariate revealed that independent prognostic factors were follwos:TNM tumor staging,Operation mode and synthetic therapy.Conclusion:The prognosis of patients with pancreatic carcinoma is determined by multiple factors. Patients of advanced TNM staging have a poorer prognosis.Radical operation and synthetic therapy could improve prognosis. Lymph node matastasis,surgical margin status and stromal tumor thrombus influence the survival time of pancreatic cancer.