| Background:Hepatic osteodystrophy is an important pathophysiological changes in liver cirrhosis, and osteoporosis is the significant clinical manifestation.Before fractures of bones,this manifestation is delitescence,which is always ignored both by patients and doctors,so osteoporosis is an important factor that affects patients life qulity. Lumbar vertebrae is most sensitive to the bone density measurement.we use 16-slices Spiral CT scanner to do bone density measurement and analyze change pattern of hepatic cirrhosis patients,which can accurately reflect bone metabolistical situation of hepatic cirrhosis patients and has advanteges of non-trauma sensitiveness accuracy and acceptableness to find HBD early.So we can diagnosis prevent osteoporosis earlier and improve prognosis of patients.Purpose:The aim was to analyze variations of bone mineral density in lumbar vertebral body and study the relationship between bone mineral density of the lumbar spine and liver cirrhosis.Methods:According to bone mineral density scanning standard,16-slices Spiral CT scanner was used to perform in the lumbar (L1～L4) spine scanning in 70 patients with liver cirrhosis and 70 healthy volunteers (controls).Data was transferred to GE Advantage Workstation (AW) 4.1 and post-processing technique (the software QCT-5000TM) was applied to analysis BMD of ROI of every slices of CT scanning. Then the statistic analysis was carried on..The patients was grouped by 50 years or Child-Pugh grade.T-test was used to statistically analyze between control and LC patient different age group. Analysis of variance was used in different Child-Pugh grade in different age group. Incidence rate of OP between cirrhosis and control cirrhosis caused by viral hepatitis type B and not was analyzed by Chi-square analysisResults:38.6% patients with LC were found to have osteoporosis, which is higher than control (p=0.004<0.05). Bone mineral density of the lumbar spine 2 to 4 in patients with liver cirrhosis was lower than control group in different age people (p value is 0.015,0.024,0.038,0.047,0.002,0.006 respectively).BMD of L1 in cirrhosis and control has no statistically significance in different age group (P value is 0.46,1 respectively).Level of mean bone mineral density of the lumbar spine gradually descent among A,B and C grade in different age group.In group smaller than 50,there is statistically signicant among A B C grade (p=0.022, p=0.007, p=0.049,),while in group larger than 50,there is statistically significant between A and C B and C grade (p=0.000, p=0.000) but no between A and B grade (p=0.238>0.05). OP incidence rate of cirrhosis caused by viral hepatitis type B was higher than not,but has no statistically significant between them.(p=0.584>0.05)Conclusions:BMD of patients with liver cirrhosis is obvious lower than control in the same age group. Patients with liver cirrhosis has various degree osteoporosis,and OP incidence rate is higher than control.The level of osteopenia and osteoporosis have close relationship with hepatopathy severity. It is important to recognize the advantage of QCT measurement of bone mineral density and clinical significance of BMD in patients with liver cirrhosis. |
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