Study On Chemical Constituents Of Dried Zingiber Officinale And Alpinia Oxyphylla Miq

The thesis is composed of four chapters. The first chapter focused on constitutents of dried ginger. Dried ginger is the dried rhizome of Zingiber officinale Roscoe (Zingiberaceae). Dried ginger is a kind of Chinese traditional medicine. Dried ginger is frequently prescribed in traditional Chinese medicine as a stomachic, antiemetic, antidiarrheal, expectorant, antiasthmatic, haemostatic and cardiotonic, for the treatment of gastrointestinal and respiratory diseases. To make a better exploitation of dried ginger, we had a research to the dried ginger cultivated in Anhui province on chemical constituents. By repeated column chromatography over silica gel, and Sephadex LH-20, and their structures were determined mainly by means of MS and NMR techniques, one new compounds (1), along with 9 known compounds (2-10) was isolated from the EtOAC fraction of the dried ginger and their structures were identified as follows:(4-E,6-E)-7-(3,4-dihydroxy-5-methoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one(1),1,7-bis(4-hydroxy-3-methoxype nyl)heptane-3,5-dione(2), 1-dehydroxy-8-Gingerdione(3),6-Gingerol(4), curcumin(5), hexahydrocurcumin(6),1-(4-dihydroxy-3-methoxy-phenyl)-7-(4,3-bisdihydrophenyl) hepane-5-dihydroxy-one(7), 1,7-bis(4-hydroxy-3-methoxyphenyl)hepane-4-dien-one (8),2-methoxyben zene-1,4-diol (9), sitosterol (10).The second chapter was focused on study of constitutents of Alpinia oxyphylla Miq. The seeds of A. oxyphylla, belonging to Zingiberaceae, are widely distributed in South China, and used as a traditional folk medicine to treat intestinal disorders, urosis, diuresis, ulceration and dementia. To make a better exploitation of A. oxyphylla, we have a deep research to chemical constituents of A. oxyphylla Miq. cultivated in Hainan province. By repeated column chromatography over silica gel, and Sephadex LH-20, and their structures were determined mainly by means of MS and NMR techniques, a new natural compound (5), along with 8 known compounds was isolated from the EtOH estract of the seeds of Alpinia oxyphyll and their structures were identified as follows:yakuchinone A (1), yakuchinone B (2), tectochrysin (3), Protocatechuic acid (4),4-methoxy-1,2-dihydrocyclobutabenzene (5), palmiticacid (6), stigmasterol (7), sitosteryl plamiate (8), daucosterol (9).The third and forth chapters reviewed the research progresses of chemical constituents and pharmacological activities of Zingiber officinale and Alpinia oxyphylla, respectively.