| ObjectiveThis subject is to be observed before and after treatment through physical improvements, psychic improvements and fasting blood glucose, two-hour postprandial blood glucose (after oral glucose anhydrous 75g), fasting insulin, two-hour postprandial insulin (after oral glucose anhydrous 75g), insulin sensitivity index, blood lipids, such as indicators and clinical point of view from impaired glucose tolerance (IGT) to diabetes evolution, in order to Shugan Hewei Liqi Huazhuo preliminary study for the treatment of traditional Chinese medicine Shuhe capsule's formulations to improve the role of the possible mechanism of IGT, as well as the regulation of glucose metabolism and blood lipids, obesity, blood pressure and other risk factors for changes in the law between the understanding of Chinese medicine.MethodsA prospective randomized single-blind clinical study of the control method. Observation of 20 cases of out-patient cases,20 cases of hospitalized patients, a total of 40 cases, a simple test group were randomly assigned to 20 cases,20 cases of the control group and the establishment of strict diagnostic criteria, inclusion criteria, exclusion criteria. Treatment group: taking capsule of Shuhe,4 capsules/time,2 times/day, for taking three courses, a course for 30 days. Control group:taking acarbose (Bayer),50mg, 3 times/day, taking meals in a row taking three courses, a course for 30 days. Designed to observe patients before and after the test form of physical records to improve the situation, laboratory indicators,the information the results of clinical input into the computer, the establishment of databases, data management, application software for simple statistical data analysis, statistical methods of information classification, test using X2, multi-group are few compared with ANOVA (analysis of variance), and adverse events,a detailed record of adverse reactions.ResultsThe treatment group patients treated by capsule of Shuhe for 3 months, the overall effect of Chinese medicine is obviously improved than the control group, with a total effective rate of 85%. And in the control group the total effective rate of overall effect of Chinese medicine is 50%. Every single physical, mental symptoms have improved significantly in the treatment group. The clinical cure rate of physical symptoms is 24.6% in treatment group,50.8% for effective rate, and 75.4% for total effective rate. But in the control group the clinical cure rate of physical symptoms is 12.2%,32.2% for effective rate, and the total effectiveness is 44.4%. The clinical cure rate of mental symptoms is 38.6% in treatment group,42% for effective rate, and 80.6% for total effective rate. But in the control group the clinical cure rate of physical symptoms is 5.5%,18.1% for effective rate, and the total effectiveness is 23.5%. Inter-group comparison showed that the therapeutic effect of the treatment group on the physical and mental side impaired glucose tolerance in patients with the Ganpibuhe Zhuoduneiyun is better than the control group After statistical processing, were significantly different (P<0.01). Treatment group and control group after treatment there was some improvement in blood glucose, compared with before treatment, the difference was significant(P<0.05-0.01), but capsule of Shuhe's P2HBG treatment in three courses after declining significantly over the control group (△P<0.05,△△P<0.01);the treatment group and control group after treatment compared also significant differences, compared with the control group, capsule of Shuhe of P2HBG more significant improvement(*P<0.05);the treatment group to improve the efficiency of glucose significantly higher(P=0.0386<0.05). Capsule of Shuhe that single-drug therapy on the physical side impaired glucose tolerance in patients with Ganpibuhe Zhuoduneiyun partial improvement in blood sugar have a good role. In glycosylated hemoglobin, body mass index, waist-hip ratio, CRP, ESR, UA, the difference between the two groups is also significant(P<0.05), efficacy of the treatment group than the control group. The treatment group have no adverse reaction, but the control group have 6 digestive system adverse reactions. So the medicine of the treatment group is much more safety than the control group.ConclusionCapsule of Shuhe in the treatment of impaired glucose tolerance have a better clinical efficacy, to refute the past, Chinese medicine in improving laboratory indicators in patients with deficiencies in the treatment of proven effectiveness of traditional Chinese medicine differentiation; In this study, a single treatment of Traditional Chinese Medicine IGT, and compared the effects of western medicine,western medicine is different from the previous joint-control study carried out to avoid the West also in therapy also may cause side-effects; Chinese medicine have hypoglycemic, lipid, weight, blood pressure and improve insulin resistance. In particular, the research into the analysis of modern medicine mental scale effect of clinical manifestations and treatment of characteristic. Such as the role of Western Although treatment can achieve good results, but also can cause metabolic disorders, and side effects, targeted single. Chinese targets, and tolerance, and unity to overcome the Western side effects caused. Therefore, the correct use of Chinese medicine treatment of impaired glucose tolerance dialectical there are a lot of prospects.
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