The Clinical Features And Correlation Factors Of Liver Injury In Infectious Mononucleosis In Children

ObjectiveTo investigate the clinial features and correalion factor of infectious mononucleosis with liver injury in children and explore possible factors, increase the awareness to liver injury in IM.MethodsCollected clinical data of 189 hospitalized patients with infectious mononucleosis between 2003 and 2008 Shengjing Hospital of China Medical University, liver injury in clinical characteristics and laboratory tests were retrospectively analyzed.Results189 cases of infectious mononucleosis in children with abnormal transaminase rate of 50.8%, serum alanine aminotransferase mild to moderately elevated, most cases in less than 2OOIU/L (82.2%), liver injury reach to 29.6%, IM with liver injury white blood cell count most in the 10-30x109/L(66.1%),the average is 20.4x109/L, liver injury group and the group without liver injury there is no significant differences on white blood cell count, liver enlarged (for less than 3 years old children counted by over rib≥2cm) accounted for 22%, mostly mild swelling, generally less than 6cm under ribs.To analize related factors there is no evidence that CRP and liver injury have correlation, while analysis by the age group shows more than 6 years of age group suffered liver injury were significantly higher than children in other groups, in addition to the lymphocyte subsets CD4+, CD8+ analysis shows, IM with liver damage in children their CD4+/CD8+ ratio reversed significantly, CD4+ cell were significantly decreased while the number of CD8+ cell increased significally on statistics. ConclusionInfectious mononucleosis with liver injury is widespread, mainly for the ALT abnormality rate was 50.8%, with mild to moderate increase in the main, liver injury reach to 29.6%.CRP is no correlation with liver injury, IM with liver damage in children,compared with cases without liver injury, CD4+/CD8+ ratio reversed significantly, CD4+ cell is significantly decreased while the number of CD8+cell increased significally on statistics. The age group of more than 6 years old suffered liver injury significantly higher than children in other groups, should arouse the pediatrician's attention for early intervention.