Analysis Of Prognostic Influencing Factor Of Transsphenoidal Microsurgery For Growth Hormone-Secreting Pituitary Adenoma

Objective:To evaluate the transphenoidal adenomectomy on patients with growth hormone-secreting adenomas and analyze the factors affecting the outcomes.Methods:37 patients of growth hormone-secreting adenomas undergoing transphenoidal adenomectomy from April 2003 to December 2009 were analyzed retrospectively. Tumor size, preoperative GH levels, tumor invasiveness, preoperative treatment and pathological type were all analyzed to evaluate the surgical outcome.Results:Total biochemical remission was achieved in 51.4%of 37 patients based on our criteria, and the post-operative biochemical remission rates of microadenornas, macroadenomas and giant adenomas were 88.9%,43.5%, and 20% respectively. The biochemical remission rates of noninvasive adenomas and invasive adenomas were 61.5% and 27.3% respectively, showing significant difference between them (P<0.05). The biochemical remission rates of preoperative GH<20μg/L,20-50μg/L,> 50μg/L group were 81.8%,50%,20%. Compared with GH<20μg/L group,20-50μg/L,> 50μg/L group showed significant difference(P<0.05).Conclusion:Transsphenoidal surgery remains the first-line reference treatment, there are high biochemical remission of the patients with microadenomas and noninvasive adenomas. The biochemical remission are related to preoperative GH level and invasiveness.