Clinical Characteristics And Gene Variation Of Measles Outbreak In Zhejiang

Background:EPI has obviously decreased the incidence of measles, still measles is one of the major causes of children deaths. Recently years locally outbreak still presence with some new clinical features, all of these bring new challenges to measles elimination.Methods:Using standardized clinical diagnosis and therapy pathway, we collected the clinical information.216 patients were divided into three groups:infants, children and adult. Withdrawal the acute phase serum, we finished the blood routine test, hepatic function test and IgM antibody test. In adult group we detected the T lymphocytes sub-type using flow cytometry.Results:216 patients were aging from 2-month-old to 46-year-old, its infectious spectrum was like a spindle. The infants and adults parts of the infectious spectrum reach a total of 81.48%. Besides some new symptoms, the clinical symptoms remain relatively typical. Different groups showed their own clinical manifestations, The major features of the infants group are cough and Korotkoff plaques, and in this group, the MV-IgM positive rate is the highest,83.67%of the infants have complications. The subjects of the children group showed the major symptoms as catarrhal,70%of which with complications. Hepatic function in the adult group is significantly abnormal. In our 78 cases adult patients, the FCM results suggest CD4 cell count and CD4/CD8 decreased significantly, and CD8 increased significantly, also CD4+CD45RA+was significantly lower than control(p<0.05), and CD8+CD45RO+was significantly higher than normal control group(p<0.05).Conclusion:The use of measles vaccine greatly change its infectious spectrum. The emergence of new clinical characteristics give us challenges for its prevention and control. At the same time, further study of the measles infectious cellular immunity mechanism still needed.