Expression And Significance Of HPV L1 Protein And IL-2 In Different Lesions Of Cervix

Objective:To elucidate the relation between HPV L1 capsid protein and IL-2 expressions in different lesions of cervix, and to explore their prognostic significance in cervical lesions.Methods:The expression of HPV L1 capsid protein and IL-2 were measured by S-P immunohistochemistry, respectively, in 22 cases of chronic cervicitis,24 cases of CINâ… , 28 cases of CINâ…¡,37 cases of CINâ…¢and 13 cases of cervical squamous cell carcinoma(SCC).Results:The expression of HPV L1 protein decreased as the cervix lesions progressed, and there was notably difference in CINâ… , CINâ…¡and CINâ…¢(p<0.05). The expression of IL-2 in chronic cervicitis and CINâ… was remarkably higher than that in CINâ…¡, CINâ…¢and SCCs (p<0.05). The expression of IL-2 was positively correlated with the expression of HPV L1 protein in tissues of CIN (p<0.05). The relation between HPV L1 protein and IL-2, IL-2(-)/L1(-)cases represented 4.17% of CINâ… ,28.57% of CINâ…¡, 59.46% of CINâ…¢, and 92.31% of SCCs, it was positively correlated with the severity of cervical lesions; whereas IL-2(+)/L1(+)cases were negatively correlated with the severity of cervical lesions, it represented 62.5% of CINâ… ,25.00% of CINâ…¡,8.11% of CINâ…¢, and 0% of SCCs.Conclusion:Expression of HPV L1 capsid protein and IL-2 decreased with lesion progression from chronic cervicitis to CIN and SCCs, they play an important role in the development of cervical intraepithelial dysplasias. The correlation between L1 and IL-2 expressions suggests that IL-2(-)/L1(-)cases have the potential for progression, whereas IL-2(+)/L1(+)cases may be nonprogressive lesions or potentially in remission.