Meta-aanalysis For The Effects Of Letrozole For Clinical Ovulation Induction

[Objective]:To evaluate the efficacy of the third-generation aromatase inhibitor(AI) of letrozole(LE)for clinical ovulation induction.[Method]:A systematic-thorough search of the literature was performed for both prospective and retrospective studies,followed by taking up the data for meta-analysis.[Results]:1.11 studies was included in the meta-analysis.2. Comparing the effects of LE with CC in patients with polycystic ovary syndrome,the pooled result was not significant for pregnancy rate per cycle(OR=1.01;95% CI 0.79～1.28),or for ovulation rate per cycle(OR=0.99;95% CI 0.69～1.43). In clomiphene-resistent infertile women with polycystic ovarian disease,LE group as compared with CC group there was no statistical difference in pregnancy rate per person(OR=1.36;95% CI 0.88～2.11),and as compared with anastrozole the pregnancy rate and ovulation rate per cycle did not show significant difference(OR=0.87;95% CI 0.55～1.37),and(OR=1.53;95% CI 0.46～5.06).3.In three retrospective studies which compared LE+FSH with FSH in ovarian stimulation for intrauterine insemination (IUI),the pooled pregnancy rate per patient was not significantly different(OR=1.15;95% CI 0.78～1.71).[Conclusion]: Letrozole is as effective as other methods of ovulation induction. It is hoped that further well designed clinical trials will be conducted to define more clearly the efficacy and safety of letrozole in human reproduction.