The Intraocular Lenses Of Nanometer Tio2-coated Implanted Into Rabbit Eyes

Objective: To prepare nanometer TiO2-coated intraocular lens and to investigate its effect and feasibility of inhibiting posterior capsule opacification of rabbit.Methods: 1.Prepare TiO2 films on PMMA substrate with the aid of air plasma treatment to produce a more hydrophilic surface on the PMMA, followed by dip-coating of TiO2 in a TiO2 sol. Scan the surface with scanning electron microscope to observe the surface shape modified by nano-TiO2 film. 2.Twelve New Zealand white rabbits(24eyes) were medially divided into 2 groups named group A and B randomly. All the crystalline lens of eyes were emulsified and evacuated of by the same operator, and then different treatment in different groups. In group A, the control group, the Polymethylmethacrylate (PMMA) IOLs were implanted. In group B, the nanometer TiO2-coated IOLs were implanted. Slit-lamp-micrographscopy, histopathologyscopy and electron-microscopescopy were performed when 180 days after the operations.Results: The surface of nanometer TiO2-coated intraocular lens is uniform formation. The results of intraocular lenses implanted into rabbit eyes show:(1) The degree of anterior chamber response in the nanometer TiO2-coated intraocular lens was lower than that in the the Polymethylmethacrylate intraocular lens when 90 days after the operations(p=0.020). (2)The degree of PCO in the nanometer TiO2-coated intraocular lens was lower than that in the the Polymethylmethacrylate intraocular lens when 90 days after the operations(p=0.025). (3)The tissue changes following intraocular lens implantion in rabbits'eyes included chronic inflammatory changes in iris and ciliary body. (4)The adherence cells on the sueface of IOLs included macrophages,fibroblasts and multinudear foreign-body giant cells.A few of adhered cells were on the surface of the central part of the intraocular lenses and more on the border of the intraocular lenses optics. The cells deposied on the surface of the intraocular leses in TiO2 modified group were less than that in non-modified group. Conclusion : With implanting nanometer TiO2-coated intraocular lens after phacoemulsification and evacuation of the crystalline lens can inhibit PCO actively and have slight toxic reaction and damage in the eyes. TiO2/PMMA IOL have good biocompatibility.