The Change Of Immune Guideline Of Body Fluid In Serum Of Depressive Patients Of Different Phases

Objective: The study investigated the change of immune guideline of body fluid of depressive patients of different phases , immunoglobulin IgA, IgG, IgM and complement C3, C4 included. This is to indefinitize the relationship of every immune guideline with the phases of depression, so that an obvious evidence of the etiology study and the clinical effect evaluaton of depression could be given. It was supposed to promote the allround development of depression.Method: 18 inpatients with depression were involved in the study. All of the subjects completed the general condition questionnaire. HAMD of the acute phase and the remission phase was evaluated by two normal trained cilnicians respectively, and IgG, IgM, IgA, C3, C4 of the two phases were detected with ELISA. Utilizing t test to statistics the collected data in SPSS 10.0.Results: The serum concentration of IgA, IgM and C3 of depression in remission phase was lower than in acute phase, and the difference of C3 was sufficient statistically. Whereas the serum concentration of IgG and C4 of the remission phase was higher than that of the acute phase, and the difference was insufficient statistically.Conclusions: The serum concentration of every body fluid immune guideline changed with the illness phases in the patients with depression. There was relationship of illness state to the function of the immune system.