Synthesis And Characterization Of Different Substituted Phenylporphyrin-5-fluorouracil Compounds

Porphyrins and metalloporphyrins are familiar in nature and they are also in animals and plants in various forms. They have special structures, so they have unique biological activities, such as heme, chlorophyll and cytochrome. Porphyrin compounds are well-directing agents. They have a special affinity for cancer cells and can stay in them. So they can locate cancer cells very well, then kill the cancer cells and cure diseases. They have a contribution to the research progress of anti-cancer drugs. Presently, the application of Porphyrins and metalloporphyrins is becoming more and more widespread. For example, they can be used as light conductor, superconductor and chromogenic agent. In addition, Porphyrins and metalloporphyrins are also applied in medicine, catalytic chemistry, material chemistry and analytical chemistry. So the research on the use of porphyrins and metalloporphyrins for tumor localization and therapy has caused great interests of chemists, medicals and biologists.5-Fluorouracil is the first generation of drug-fluorouracil. In clinic, such drug has been known for people. As a kind of antitumor drug, 5-fluorouracil has a very clear anti-metabolic function that can act on the DNA, and through a variety of ways to interfere with the synthesis of DNA, and thus inhibit the proliferation of tumor cells. But there are unassailable faults. One of them is that the toxic effective dose is close to drug dose, that is, it also seriously hurts the normal cells while it kills the cancer cells.So, in order to find more effective 5-fluorouracil anti-cancer drugs, we linked different porphyrins to dibromoalkane with different carbon chain lengths, then connected them to 5-fluorouracil and synthesized relevant porphyrin-5-fluorouracil compounds and their metalloporphyrin compounds. We expected that they could reduce the toxicity of 5-fluorouracil and boost up their activity of anticancer.In the paper, we have synthesized and charactered ten new phenylporphyrin-5-fluorour- acil compounds and five novel copper-5-fluorouracil compounds. The results are as follows: Firstly, we have explored the conditions of experiment and synthesized the target compounds.Secondly, we have characterized the structures of ten porphyrin-5-fluorouracil compounds by MS, 1HNMR, IR and UV-Vis. The structures of five novel copper-5-fluorouracil compounds have been characterized by IR and UV-Vis.Thirdly, we have improved the conditions of separaion and purification. The results were very well.