Clinical Study On The Significance Of The Gastric Intramucosal PH In Early Prognosis On Acute Intracerebral Hemorrhage Patients

Objectve: The gastric intramucosal PH (PHi) monitoring has widely applicable value in the diagnosis and treatment for different serious illness. It is a primitive, sensitive, economical and depensable monitoring method. The text had been done to study the clinical significance of the gastric intramucosal PH. It provide experimental evidence for the clinic diagnosis and prognosis on acute intracebral hemorrhage patients. It raises the diagnosis and treatment levels on acute intracebral hemorrhage patients. .It bring down the complications and mortalities of acute intracebral hemorrhage patients.Methods: Texts had been done on the gastric intramucosal PH(PHi) of 38 acute intracerebral hemorrhage patients in the neurology of the first affiliate hospital of Henan University. Among these patients . there are 21 males and 17 females, aged 40-80 years. The average age is 60.25±8.20 years. 28 patients merge hypertension and 18 merge diabete. The amount of blooding≥30ml is 15, and <30ml 23 (the number of putminal hemorrhage is 25, thalamic hemorrhage 9 and brainstem hemorrhage 4). All these disease accord with the diagnostic criteria of"Diagnostic Poit of All Naoxueguanbing"which is altered in chinese nerves academy,1995. The Glasgow Coma Score of these patients is 3-10. All these patients were given the conventional therapy. We measure the gastric intramucosal PH on these patients,and then compare with APACHⅡ( Acute Physiologic and Chronic Heath Evaluation )and GCS (Glasgow Coma Score)on the first 30 minites and the first 24 hours after been admitted to hospital. These patients are scored according the SOFA score (Sepsis-related Organ Failure Assessment) and Goris's MOF(Multiple Organ Failure)score in the first week . The patients are devided into survival group and dead group,no MODS(Multiple Organ Dysfunction Syndrome)complication group and MODS complication group. We analyse which one is the most sensitive method to pridict the prognosis and complication of the acute intracebral hemorrhage patients. The salt water tension instrument method is adopt in monitoring the gastric intramucosal PH. Datas were expressed as means±SEM, analysis were done by SPSS 12.0, P < 0.05 was considered significant , P < 0.01 was highest significant.Results: Among the 38 cases,11 cases died within 1 week. Comparing dead and survival group,in the beginning 30 minites ,the results of the gastric intramucosal PH (PHi) decreased dramatically(P<0.05),but the APACHⅡwere the same(P>0.05) and GCS were the same(P>0.05).After 24 hours,comparing with the two groups,the results of PHi were different (P<0.01),the APACHⅡw ere different (P<0.05) and GCS were different (P<0.05). 8 cases among these 38 cases suffered from Multiple Organ Dysfunction (MODS). Comparing with the other group, in the beginning 30 minites,the results of PH (PHi) were significantly lower (P<0.05),but the APACHⅡwere the same (P>0.05) and the GCS were the same (P>0.05 ) .After 24 hours the results of PH (PHi) were significantly lower (P<0.01),while the APACHⅡwere higher (P<0.05) and the GCS were lower (P<0.05).Conclusion: As one early detector of ischemia of internal organs,the gastric intramucosal PH(PHi) has important clinical significance in early prognosis in acute intracerebral hemorrhage patients.