Study On The Correlation Between ADMA And Cerebrovascular Reactivity In Patients With Cerebral Infarction

ObjectiveThis study observed the relationship among ADMA,cerebrovascular reactivity and cerebral infarction, and the correlation between ADMA and cerebrovascular reactivity through measuring the level of plasma asymmetric dimethylarginine (ADMA) , cerebrovascular reactivity of cerebral infarction patients, to explore the role of ADMA in cerebrovascular autoregulation .MethodsThe study was designed in the first hospital affiliated to Soochow University between February 2009 and January 2010. we selected Fifty-seven patients with cerebral infarction .atherothrombotic infarction (AI)group ( n=30 ), lacunar infarction(LI) group(n=27),and 25sex-and age-matched healthy volunteers. plasma asymmetric dimethylarginine were measured by enzyme linked immunosorbent assay (ELISA), whereas fasting plasma glucose, triglycerides, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol were measured by automatic biochemistry analyzer. and in the same time carotid artery intima-media thickness were examined by using neck artery ultrasound.Cerebral hemodynamics changes were measured by transcranial Doppler.and recorded the hemorheological parameters,and calculated the breath-holding index . All statistical analysis were performed using the Statistical Package for Social Science(SPSS for Windows, Version 16.0)Results1 The breath-holding index of atherothrombotic infarction group and lacunar infarction group were significantly lower than normal contro(lP<0.05). but the difference of sub-group was not significant (P>0.05).2 Plasma asymmetric dimethylarginine levels of atherothrombotic infarction group and lacunar infarction group were significantly higher than normal control(P<0.05).and plasma asymmetric dimethylarginine levels of atherothrombotic infarction group was significantly higher than lacunar infarction group(P<0.05).3 Logistic regression analysis showed that systolic pressure. carotid artery intima-media thickness the breath-holding index and ADMA were respectively independent risk factor for cerebral infarction.4 The breath-holding index was positively correlated with high density lipoprotein cholesterol,and was negatively correlated with carotid artery intima-media thickness.5 Asymmetric dimethylarginine were positively correlated with systolic pressure. carotid artery intima-media thickness. triglyceride.total cholesterol.6 The partial correlation analysis suggested that the breath-holding index was negatively correlated with ADMA .Conclusions1 The plasma asymmetric dimethylarginine levels of acute cerebral infarction patients was increased, cerebrovascular reactivity was decreased, plasma ADMA, cerebrovascular reactivity may be independent risk factors of cerebral infarction.2 Plasma asymmetric dimethylarginine levels was negatively correlated with cerebrovascular reactivity, positively correlated with systolic pressure. carotid artery intima-media thickness. triglyceride.total cholesterol .the elevated plasma asymmetric dimethylarginine levels may affected endothelial function,reduced the cerebrovascular reactivity, then promoting the development of cerebral infarction.